FGF-23 (human):Fc (human, rec.)

FGF-23 (human):Fc (human, rec.)
%
Item number Size Datasheet Manual SDS Delivery time Quantity Discount Price
AG-40A-0109-C010 10 µg -

3 - 9 business days*

10 %
204.00€
183.60€
AG-40A-0109-C050 50 µg -

3 - 9 business days*

10 %
440.00€
396.00€
 
Signal peptide and human FGF-23 (amino acids 1-251) are fused at the C-terminus to the Fc portion... more
Product information "FGF-23 (human):Fc (human, rec.)"
Signal peptide and human FGF-23 (amino acids 1-251) are fused at the C-terminus to the Fc portion of human IgG1. Activates ERK and FRS2alpha phosphorylation in Klotho expressing cells. Liquid. 0.2µm-filtered solution in PBS. FGF-23 (Fibroblast growth factor 23) is a regulator of phosphate homeostasis. It upregulates EGR1 expression in the presence of KLBy. Acts directly on the parathyroid to decrease PTH secretion. Regulates the vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. Defects in FGF-23 are the cause of autosomal dominant hypophosphataemic rickets (ADHR) and of hyperphosphatemic familial tumoral calcinosis (HFTC).
Keywords: Fibroblast Growth Factor 23, Tumor-derived Hypophosphatemia-inducing Factor
Supplier: AdipoGen Life Sciences
Supplier-Nr: AG-40A-0109

Properties

Application: Bioassays
Conjugate: No
Host: Human cells
Species reactivity: human
MW: 60 kD
Format: Liquid

Database Information

KEGG ID : K22428 | Matching products
UniProt ID : Q9GZV9 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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