- Search results for Cay10010231
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11 products were found matching "Cay10010231"!
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Item number: Cay10010231-1
Fatty acid binding protein 4 (Adipocyte-FABP, aP2, FABP4) is one of nine known cytosolic fatty acid binding proteins ranging in size from 14-15 kDa containing 127-132 amino acids. FABP4 is highly expressed in adipocytes and is regulated by peroxisome-proliferator-activated receptor-gamma (PPARgamma) agonists,...
Keywords: | A-FABP, Adipocyte FABP, ALBP, aP2, Fatty Acid Binding Protein 4 |
Application: | FABP4 inhibitor screening, FABP4 ligand screening |
395.00€
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Item number: Cay10010233-1
Akt1, 2, and 3 are serine/threonine protein kinases in the phosphatidylinositol 3 (PI3)-kinase signalling pathway that play a critical role in the regulation of cell proliferation and survival. Following recruitment of Akt to the plasma membrane, phosphorylation at threonine 308 and serine 473 (Akt1 numbering) by...
Keywords: | BML-257, 2,3-diphenyl-6-quinoxalinecarboxylic acid |
Application: | Akt1 translocation inhibitor |
CAS | 32387-96-5 |
MW: | 326.4 D |
From 38.00€
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Item number: Cay10010237-1
Triciribine is an Akt activation inhibitor and a prodrug form of triciribine phosphate (Cay-37985). It reduces levels of phosphorylated Akt1, -2, and -3 in Akt-overexpressing NIH3T3 cells when used at a concentration of 1 µM. Triciribine is selective for Akt1, -2, and -3 over a panel of seven other Akt-activating...
Keywords: | API 2, NSC 154020, Tricyclic Nucleoside, 1,5-dihydro-5-methyl-1-beta-D-ribofuranosyl-1,2,5,6,8-pentaazaacenaphthylen-3-amine |
Application: | Akt inhibitor |
CAS | 35943-35-2 |
MW: | 320.3 D |
From 64.00€
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Item number: Cay10010235-1
Terreic acid (TA) is a cell-permeable quinone epoxide that selectively inhibits Bruton's tyrosine kinase (BTK) catalytic activity (IC50s = 10 and 3 µM for basal and activation levels, respectively). TA binds to the BTK pleckstrin homology domain (BTK-PH) and blocks the interaction between BTK-PH and PKC (IC50 = 100...
Keywords: | (-)-Terreic Acid, TA, (1R,6S)-3-hydroxy-4-methyl-7-oxabicyclo[4.1.0]hept-3-ene-2,5-dione |
Application: | Cell-permeable BTK inhibitor |
CAS | 121-40-4 |
MW: | 154.1 D |
From 92.00€
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Item number: Cay10010239-1
The development of selective, cell-permeable protein kinase inhibitors for the treatment of cancer, inflammation, and other diseases, is a major focus of drug development efforts. Kenpaullone is an ATP-competitive inhibitor of several cyclin-dependent kinases (CDKs) as well as glycogen synthase kinase 3beta...
Keywords: | 9-Bromopaullone, NSC 664704, 9-bromo-7,12-dihydro-indolo[3,2-d][1]benzazepin-6(5H)-one |
Application: | CDK inhibitor, GSK-3 beta inhibitor |
CAS | 142273-20-9 |
MW: | 327.2 D |
From 66.00€
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Item number: Cay10010238-1
Overactivity of the epidermal growth factor (EGF) receptor-associated tyrosine kinase has been associated with a number of cancers and thus tyrosine kinase inhibitors could be potential therapeutic agents to prevent malignant growth. Erbstatin is a potent, small-molecule inhibitor of EGF receptor-associated tyrosine...
Keywords: | Methyl 2,5-dihydoxycinnamate, 3-(2,5-dihydroxyphenyl)-2-propenoic acid, methyl ester |
Application: | EGF receptor kinase inhibitor |
CAS | 63177-57-1 |
MW: | 194.2 D |
From 19.00€
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Item number: Cay10010243-1
The HER2/Neu proto-oncogene is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases (RTK) which includes EGFR, HER2/Neu, HER3 and HER4. Overexpression of HER2/Neu occurs in 25-30% of human breast and ovarian cancer. AG-825 is a selective ATP-competitive inhibitor of the...
Keywords: | Tyrphostin AG-825, 3-[3-[(2-benzothiazolylthio)methyl]-4-hydroxy-5-methoxyphenyl]-2-cyano-2-propenamide |
Application: | HER-2/neu inhibitor |
CAS | 149092-50-2 |
MW: | 397.5 D |
From 38.00€
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Item number: Cay10010293-1
Cyclic phosphatidic acids (cPAs) are naturally occurring analogs of lysophosphatidic acid (LPA) in which the sn-2 hydroxy group forms a 5-membered ring with the sn-3 phosphate. Carba-derivatives of cPA (ccPA) are modified at the sn-2 (2-ccPA) or sn-3 (3-ccPA) linkage, preventing the opening of cPA to produce LPA....
Keywords: | 3-ccPA 16:0, (2-hydroxy-2-oxido-1,2-oxaphospholan-5-yl)methyl ester-hexadecanoic acid |
Application: | Autotaxin inhibitor |
CAS | 476310-22-2 |
MW: | 390.5 D |
From 102.00€
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Item number: Cay10010623-1
Linoleic acid is an essential fatty acid and one of the most abundant polyunsaturated fatty acids (PUFAs) in the western diet. Deficiencies in linoleic acid are linked to defective wound healing, growth retardation, and dermatitis. Linoleic acid is metabolized by 15-LO in both plants and animals to form 9- and...
Keywords: | 9Z,12Z-octadecadienoyl-N'-biotinoyl-1,5-diaminopentane |
Application: | Bioactive lipid assays |
MW: | 520.8 D |
From 77.00€
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Item number: Cay10010723-1
The actions of many clinical F-series prostaglandins (PGs), including those used for estrous synchronization and reduction of intraocular pressure (IOP), are mediated through the PGF2alpha (FP) receptor. 17-phenoxy PGF2alpha isopropyl ester is an analog of PGF2alpha containing a 17-phenoxy group on the lower side...
Keywords: | 17-phenoxy-PGF2alpha isopropyl ester, 9alpha,11alpha,15S-trihydroxy-17-phenoxy-prosta-5Z,13E-dien-1-oic acid, isopropyl ester |
Application: | Bioactive lipid assays |
MW: | 446.6 D |
From 86.00€
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Item number: Cay10010263-1
Formulation: (Request formulation change), 10 ml of 250 mM Tris-HCl, pH 7.6, containing 750 mM sodium chloride, 5% NP-40, 2.5% sodium deoxycholate, and 0.5% SDS.
Application: | Kit component |
50.00€
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