Epstein Barr Virus Induced 3, His Tag, human recombinant (rHuEBI3-His)

Epstein Barr Virus Induced 3, His Tag, human recombinant (rHuEBI3-His)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
97282.2 2 µg - -

3 - 10 business days*

94.00€
97282.10 10 µg - -

3 - 10 business days*

208.00€
97282.1 1 mg - -

3 - 10 business days*

6,989.00€
 
Cytokine with pro- and anti-inflammatory properties, that can regulate T helper cell development,... more
Product information "Epstein Barr Virus Induced 3, His Tag, human recombinant (rHuEBI3-His)"
Cytokine with pro- and anti-inflammatory properties, that can regulate T helper cell development, suppress T-cell proliferation, stimulate cytotoxic T cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines. (www.uniprot.org) Human recombinant EBI produced in E.coli is a single, non-glycosylated, polypeptide chain containing 209 amino acids fragment (21-229) having a molecular weight of 34kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. EBI3 has an induced expression in B lymphocytes in reaction to Epstein-Barr virus infection. EBI3 encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form iIL-27. EBI3 drives rapid clonal expansion of naive cd4() t-cells. EBI3 strongly synergizes with IL-12 to activate IFN-gamma production of naive cd4() t-cells. EBI3 mediates its biologic effects through the cytokine receptor wsx-1/tccr.
Keywords: IL27B, Interleukin-27 subunit beta, IL-27 subunit beta, IL-27B, Epstein-Barr virus-induced gene 3 protein, EBV-induced gene 3 protein, EBI3
Supplier: Biomol GmbH
Supplier-Nr: 97282

Properties

Application: Bioassay
Conjugate: No
Host: E.coli
Species reactivity: human
Purity: >95%
Format: Purified

Database Information

UniProt ID : Q14213 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Epstein Barr Virus Induced 3, His Tag, human recombinant (rHuEBI3-His)"
Write a review
or to review a product.
Viewed