(-)-Epigallocatechin gallate

Potent anticancer compound - Anti-angiogenic. VEGF, VE-cadherin phosphorylation, matrix metalloproteinase and urokinase-plasminogen activator (uPA) inhibitor - Anti-inflammatory. NF-kappaB inhibitor. Modulates chronic inflammatory diseases, such as type 2 diabetes, rheumatoid arthritis, inflammatory bowel disease - COX-2 and inducible nitric oxide synthase (iNOS, NOS II) inhibitor - Potent antioxidant. Protects cells from lipid peroxidation and DNA damage induced by reactive free radicals - Regulates cancer cell growth, proliferation, transformation, survival, angiogenesis, apoptosis, invasion and metastasis - Chemopreventive. Apoptosis inducer. Promotes cell cycle arrest - Modulates signal transduction pathways including JAK/STAT, MAPK, PI3K/AKT, Wnt and Notch - EGFR and HER-2 receptor signaling inhibitor - MAPKs and activator protein-1 inhibitor - mTOR suppressor - IGF-I signaling inhibitor - Proteasome inhibitor - Telomerase and DNA methyltransferase inhibitor - Selective and noncompetitive HAT inhibitor - Topoisomerase I and II inhibitor - Hedgehog signaling (Hh) modulator. PTCH and Gli1 inhibitor - Wnt signaling inhibitor - Neuroprotective. Activates HO-1 by the ARE/Nrf2 pathway, protecting neurons against oxidative damage - STAT-1 inhibitor - Shows preventive cardiovascular and metabolic (obesity, insulin resistance, hypertension and hypercholesterolemia) effects - Inhibits extracellular signal-related kinases (ERK), activates AMP-activated protein kinase (AMPK), modulates adipocyte marker proteins and down-regulates lipogenic enzymes as well as other potential targets - Fatty acid synthase (FAS) inhibitor.