Epidermal Growth Factor Receptor, L858R, Recombinant, Human (erbB, EGFR)

Epidermal Growth Factor Receptor, L858R, Recombinant, Human (erbB, EGFR)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
E3375-48A.10 10 µg - -

3 - 19 business days*

955.00€
 
The L858R mutation has been associated with non-small cell lung cancer patients who demonstrate... more
Product information "Epidermal Growth Factor Receptor, L858R, Recombinant, Human (erbB, EGFR)"
The L858R mutation has been associated with non-small cell lung cancer patients who demonstrate clinical responsiveness to the tyrosine kinase inhibitor gefitinib (Iressa, ZD1839). Source: Recombinant human EGFR L858R, aa668-1210, with N-terminal GST tag, expressed in baculovirus expression system. Molecular Weight: 88kD , Specific Activity: , 317pmol/min/ug, Reaction Buffer: 50mM HEPES (pH7.5), 10mM MgCl2, 1mM EDTA, 0.01% BRIJ- 35 and 200uM of ATP. Substrate: 2uM Tyr peptide 4 from Invitrogen. Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. Other applications not tested. Recommended Dilution: The enzyme reaction was carried out for 1h at room temperature in reaction buffer. Optimal dilutions to be determined by the researcher. Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for at least 6 months.
Keywords: EC=2.7.10.1, Proto-oncogene c-ErbB-1, Epidermal growth factor receptor, Receptor tyrosine-protein kinase erbB-1
Supplier: United States Biological
Supplier-Nr: E3375-48A

Properties

Conjugate: No
MW: 88 kD
Purity: 70%
Format: Highly Purified

Handling & Safety

Storage: -80°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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