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HVEM/TNFRSF14, also known as tumor necrosis factor receptor superfamily member 14, is a member of TNF receptor superfamily. This protein was originally known as herpes virus entry mediator A (HveA), HveB and HveC are structurally unrelated proteins of the immunoglobulin superfamily. The cytoplasmic region of this...

IL-9, also known as interleukin 9, is a cytokine (cell signalling molecule) belonging to the group of interleukins. This protein produced by T-cells and specifically by CD4+ helper cells that acts as a regulator of a variety of hematopoietic cells and stimulates cell proliferation and prevents apoptosis. It...

SPARC1, also known as SPARC-like protein 1, is a secreted protein with high structural similarity to SPARC. This protein as an anti-adhesive protein that is widely expressed in tissues such as brain, heart, lung, muscle and kidney, but not liver. It inhibits adhesion and spreading on a variety of substrates and is...

Vitronectin, also known VTN, is a member of the pexin family. It is a cell adhesion and spreading factor foundin serum and tissues. This protein interacts with glycosaminoglycans and proteoglycans and is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. It also...

SUMF1, also known as sulfatase-modifying factor 1 isoform 1, is a Ca2+-binging member of the sulfatase-modifying factor family. This protein as soluble ER lumenal glycoprotein converts inactive sulfatases into an active form by transforming a catalytic site cysteine into a formylglycine residue. In the ER, it can...

Thioredoxin-1 is a low molecular weight redox protein. Thioredoxin-1 contains a redox active disulfide/dithiol group within the conserved Cys-Gly-Pro-Cys active site. It is involved in the first unique step in DNA, synthesis. Thioredoxin-1 also provides control over a number of transcription factors affecting cell...

Thrombopoietin (THPO), also known as megakaryocyte growth and development factor (MGDF), is a glycoprotein hormone produced by the liver and kidney which regulates the production of platelets. It stimulates the production and differentiation of megakaryocytes, the bone marrow cells that bud off large numbers of...

TNF-alpha, also known as tumor necrosis factor, is the prototypic ligand of the TNF superfamily. It is a pleiotropic molecule that plays a central role in inflammation, apoptosis, and immune system development. This protein is produced by a wide variety of immune and epithelial cell types. It is assembled...

RELT, also known tumor necrosis factor receptor superfamily member 19L, is one of the the tumor necrosis factor receptor superfamily. It is expressed in hematopoietic tissues and peripheral blood leukocytes. This protein mediates activation of NF-kappa-B and plays a role in T-cell activation. With overexpression of...

TRANCE, also known as tumor necrosis factor ligand superfamily member 11, is a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. TRANCE also has a function in the immune system, where it is...