Glycitein is an O-methylated isoflavone that comprises 5-10% of the total isoflavones in soy food products. This phytoestrogen is reported to have weak estrogenic activity, displacing estradiol binding at the estrogen receptor in vitro with an IC50 value of 3.94 µM. It suppresses the proliferation of osteoblasts and...

The asarones, including alpha-asarone (Cay-11681) and beta-asarone, were first isolated from volatile oils of plants of the genus Acorus, which are used in Ayurvedic medicine. beta-Asarone is noted for its neuroprotective effects, as it ameliorates depression, reduces dopamine-induced neurotoxicity, and attenuates...

Epithelial cell-transforming sequence 2 oncogene (ECT2) is a guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP from small GTPases of the Rho family, such as RhoA, RhoC, Rac1, and Cdc42. ECT2 GEF activity plays an essential role during cytokinesis. ECT2 contains a DH (DBL-homology)...

Fludarabine is an intermediate active metabolite of the prodrug fludarabine phosphate (Cay-14251). It is produced by the dephosphorylation of fludarabine phosphate in vivo and re-phosphorylation intracellularly to 2-fluoro-ara-ATP, another active metabolite. Fludarabine inhibits the proliferation of RPMI-8226,...