10 products were found matching "Cay10354-25"!

No results were found for the filter!
Ticagrelor
Ticagrelor

Item number: Cay15425-25

Ticagrelor is a reversible antagonist of the platelet purinergic P2Y12 receptor (Ki = 14 nM, IC50 = 1.8 µM), which is the main receptor responsible for ADP-induced platelet aggregation. It functions by directly changing the conformation of the P2Y12 receptor to inhibit ADP binding. Formulations containing ticagrelor...
Keywords: AR-C 126532XX, AZD 6140,...
Application: P2Y12 receptor antagonist
CAS 274693-27-5
MW: 522.6 D
From 43.00€ *
Review
Anti-Chemokine-Like Receptor 1
Anti-Chemokine-Like Receptor 1

Item number: Cay10325-1

Chemokine-Like Receptor 1 (CMKLR1) is a G protein-coupled receptor relevant to the cellular chemotaxis of dendritic cells and macrophages. This receptor is also expressed in brain, liver, lung, and kidney tissues. Chemerin, or TIG2, has been identified as the natural ligand for this receptor. Resolvin E1 has also...
Keywords: Anti-CMKLR1, Anti-CHEMR23, Anti-Chemokine-like receptor 1, Anti-Chemokine-like receptor 1, Anti-G-protein coupled receptor...
Application: FC, IF, IHC, WB
Host: Rabbit
Species reactivity: human
422.00€ *
Review
SMER3
SMER3

Item number: Cay15324-25

SMER3 is a selective inhibitor of Skp1-Cullin-F-box (SCF)MET30 ubiquitin ligase, an E3 ligase that regulates transcription, cell-cycle control, and immune response. It is a small molecule enhancer of rapamycin (Cay-13346), in that it enhances yeast cell lethality in response to rapamycin. SMER3, at 5 µM, upregulates...
Keywords: MET30 Antagonist, SCFMET30 Inhibitor, 9H-indeno[1,2-e][1,2,5]oxadiazolo[3,4-b]pyrazin-9-one
Application: Skp1-Cullin-F-box (SCF)Met30 ubiquitin ligase inhibitor
CAS 67200-34-4
MW: 224.2 D
From 109.00€ *
Review
Hexacosanoic Acid
Hexacosanoic Acid

Item number: Cay13354-250

Hexacosanoic acid is a 26-carbon saturated (26:0) very-long-chain fatty acid. Plasma levels of hexacosanoic acid are increased in a mouse model of adrenoleukodystrophy, a peroxisomal disorder. Increased levels of hexacosanoic acid in red blood cells or in plasma positively correlated with atherosclerotic risk...
Keywords: C26:0, Ceric Acid, Cerotic Acid, NSC 4205, hexacosanoic acid
Application: Bioactive lipid assays
CAS 506-46-7
MW: 396.7 D
From 84.00€ *
Review
STO-609 (acetate)
STO-609 (acetate)

Item number: Cay15325-25

STO-609 is a calcium/calmodulin-dependent protein kinase kinase (CaMKK) inhibitor (IC50s = 120 and 40 ng/ml for CaMKKalpha and CaMKKbeta, respectively). It is selective for CaMKKs over CaMKI, CaMKII, CaMKIV, MLCK, PKC, PKA, and p42 MAPK (IC50s = > 10,000 ng/ml for all). STO-609 inhibits phosphorylation of CaMKI and...
Keywords: 7-oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid, monoacetate
CAS 1173022-21-3
MW: 374.4 D
From 43.00€ *
Review
CAY10683
CAY10683

Item number: Cay15403-25

CAY10683 is a potent histone deacetylase (HDAC) inhibitor isolated from the cyanobacterium Symploca. It inhibits HDAC2 and HDAC6 with IC50 values of 0.119 and 434 nM, respectively, and is without effect against HDAC4 (IC50 = >1,000 nM). CAY10683 inhibits the growth of HCT116 colon cancer cells and HuT-78 cutaneous T...
Keywords: Santacruzamate A, N-[4-oxo-4-[(2-phenylethyl)amino]butyl]-carbamic acid, ethyl ester
Application: HDAC inhibitor
CAS 1477949-42-0
MW: 278.4 D
From 64.00€ *
Review
Desethoxy Quetiapine (hydrochloride)
Desethoxy Quetiapine (hydrochloride)

Item number: Cay35410-25

Desethoxy quetiapine is an active metabolite of the atypical antipsychotic quetiapine (Cay-14152). It is formed from quetiapine primarily by the cytochrome P450 (CYP) isoform CYP3A5 and binds to dopamine D2 receptors (IC50 = 1,330 nM). Desethoxy quetiapine (20 and 40 mg/kg) reduces climbing induced by the dopamine...
Keywords: O-Desalkylquetiapine, 4-dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazineethanol, dihydrochloride
Application: Quetiapine active metabolite
CAS 329218-14-6
MW: 412.4 D
From 225.00€ *
Review
Copanlisib
Copanlisib

Item number: Cay20354-25

Copanlisib is an inhibitor of class I phosphoinositide 3-kinase (PI3K) isoforms (IC50s = 0.5, 3.7, 6.4, and 0.7 nM for alpha, beta, gamma, and delta, respectively). It is weakly active or inactive against numerous other kinases. Copanlisib is effective in vivo when administered intravenously, inhibiting PI3K...
Keywords: BAY 80-6946,...
Application: Class I PI3K isoform inhibitor
CAS 1032568-63-0
MW: 480.5 D
From 82.00€ *
Review
Lipid-based Drug Delivery Tools
Lipid Nanoparticle (LNP-102) Exploration Kit
Lipid Nanoparticle (LNP-102) Exploration Kit

Item number: Cay35425-1

Cayman's Lipid Nanoparticle (LNP-102) Exploration Kit is intended to serve as a starting point for laboratories to explore the feasibility of using LNPs for their individual application without the need for specialized equipment. Optimal preparation conditions for the encapsulation of oligonucleotides with LNPs must...
Application: SM-102-containing LNP preparation
354.00€ *
Review
CAY10455
CAY10455

Item number: Cay10005072-500

CAY10455 is a labeled analog of arachidonoyl ethanolamide (anandamide, AEA) that is non-fluorescent when outside the cell. Upon transport into the cell interior, it is cleaved by esterases to give a bright fluorescence at 530 nm. CAY10455 uptake into C6 glioma cells is inhibited by AEA and its analogs, and...
Keywords: SKM 4-45-1,...
Application: Bioactive lipid assays
CAS 290374-09-3
MW: 804.9 D
From 77.00€ *
Review