12 products were found matching "Cay10354"!

Prostaglandin E synthase-1 (PGES-1) catalyzes the isomerization of PGH2 to PGE2. PGE2 is one of the primary COX products of arachidonic acid and one of the most widely investigated PGs. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation. PGES-1 is a 16...

Resveratrol is a potent phenolic antioxidant found in grapes, red wine, and various berries that also has antiproliferative and anti-inflammatory activity. cis-Resveratrol is the double bond isomer of trans-resveratrol, the more often studied and naturally abundant of the two resveratrol isomers. cis-Resveratrol...

CD34 is a transmembrane phosphoglycoprotein and sialomucin protein that is commonly used as a marker for hematopoietic progenitor cells. It is composed of an N-terminal signaling peptide, a sialylated and O-glycosylated extracellular mucin domain, a cysteine-containing globular domain, a juxtamembrane stalk region,...

Poly(ADP-ribose) polymerase (PARP) is a critical DNA repair enzyme involved in DNA single-strand break repair via the base excision repair pathway. PARP1 is activated by DNA damage. Inhibiting its activity has been linked to synthetic lethality and loss of either of the breast cancer susceptibility genes, BRCA1 and...

PNU 120596 is a positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor (nAChR), increasing agonist-evoked calcium flux (EC50 = 216 nM). It has no detectable effect on alpha4beta2, alpha3beta4, or alpha9beta10 nAChRs. PNU-120596 increases the frequency of ACh-evoked GABAergic...

GPR17 is a G protein-coupled receptor that has been identified as a dualistic receptor recognizing signals from two unrelated chemical families: nucleotides and cysteinyl leukotrienes (CysLTs). The deorphanization of GPR17 supports the suggested crosstalk between nucleotides and CysLTs during inflammation and...

4-methoxy-alpha-Pyrrolidinopropiophenone (hydrochloride) (Cay-10394), also known as MOPPP, is an analytical reference standard that is structurally categorized as a cathinone. It is a designer drug that has appeared on the illicit drug market. Its metabolism in rats has been described. The physiological and...

Prostaglandin E2 (PGE2) isopropyl ester is a more lipophilic form of the free acid, PGE2. PG esters have enhanced lipid solubility compared to their parent compounds. They are generally hydrolyzed to the free acid by endogenous esterases upon in vivo administration, making the esters useful prodrugs. In general, the...

(R)-Bromoenol lactone-d7 ((R)-BEL-d7) is intended for use as an internal standard for the quantification of (R)-BEL by GC- or LC-MS. The phospholipases are an extensive family of lipid hydrolases that function in cell signaling, digestion, membrane remodeling, and as venom components. The calcium-independent...

2-(3-pyridyl)-Benzimidazole is a synthetic intermediate useful for pharmaceutical synthesis.Formal Name: 2-(3-pyridinyl)-1H-benzimidazole. CAS Number: 1137-67-3. Synonyms: G 514, NSC 62610. Molecular Formula: C12H9N3. Formula Weight: 195.2. Purity: >98%. Formulation: (Request formulation change), A crystalline...

THZ1-R is a non-cysteine reactive derivative of the cyclin-dependent kinase 7 (Cdk7) inhibitor THZ1 (Cay-9002215). THZ1-R inhibits Cdk7 (IC50s = 142-241 nM) less potently than THZ1 and lacks antiproliferative activity against T cell acute lymphoblastic leukemia (T-ALL) cell lines.Formal Name:...

CAY10683 is a potent histone deacetylase (HDAC) inhibitor isolated from the cyanobacterium Symploca. It inhibits HDAC2 and HDAC6 with IC50 values of 0.119 and 434 nM, respectively, and is without effect against HDAC4 (IC50 = >1,000 nM). CAY10683 inhibits the growth of HCT116 colon cancer cells and HuT-78 cutaneous T...