Dorsomorphin

Dorsomorphin
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay11967-5 5 mg -

6 - 10 business days*

73.00€
Cay11967-10 10 mg -

6 - 10 business days*

123.00€
Cay11967-25 25 mg -

6 - 10 business days*

234.00€
Cay11967-50 50 mg -

6 - 10 business days*

432.00€
 
Dorsomorphin is a potent, reversible inhibitor of AMPK (Ki = 109 nM) that does not exhibit... more
Product information "Dorsomorphin"
Dorsomorphin is a potent, reversible inhibitor of AMPK (Ki = 109 nM) that does not exhibit significant activity on structurally related kinases, including ZAPK, SYK, PKCtheta, PKA, and JAK3. Dorsomorphin can also dose-dependently inhibit the bone morphogenetic protein type 1 receptors ACTR-I (ALK2), BMPR-IA (ALK3), and BMPR-IB (ALK6). Independent of AMPK inhibition, dorsomorphin at 10 µM has additionally been shown to downregulate the Akt/mTOR pathway to induce autophagy in U251 human glioma cells.Formal Name: 6-[4-[2-(1-piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidine. CAS Number: 866405-64-3. Synonyms: BML-275, Compound C. Molecular Formula: C24H25N5O. Formula Weight: 399.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2.5 mg/ml, DMSO: 1 mg/ml*. lambdamax: 204, 301 nm. SMILES: N1(CCOC2=CC=C(C(C=N3)=CN4C3=C(C5=CC=NC=C5)C=N4)C=C2)CCCCC1. InChi Code: InChI=1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2. InChi Key: XHBVYDAKJHETMP-UHFFFAOYSA-N.
Keywords: BML-275, Compound C, 6-[4-[2-(1-piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidine
Supplier: Cayman Chemical
Supplier-Nr: 11967

Properties

Application: AMPK inhibitor, autophagy inducer
MW: 399.5 D
Formula: C24H25N5O
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 866405-64-3| Matching products
KEGG ID : K07199 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H302, H312, H332
P Phrases: P261, P264, P270, P271, P280, P312, P321, P330, P301+P310, P302+P352, P304+P340, P361+P364, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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