- Search results for Cay10460
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9 products were found matching "Cay10460"!
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Item number: Cay10460-5
The stress-activated p38 mitogen-activated protein kinase (MAPK) plays a critical role in regulating the production of proinflammatory cytokines such as tumor necrosis factor and interleukin-1. Doramapimod is a highly potent inhibitor of p38 MAPK with a Kd value of 0.1 nM that blocks TNFalpha release in...
Keywords: | BIRB-796, N-[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]-urea |
Application: | p38 MAPK inhibitor |
CAS | 285983-48-4 |
MW: | 527.7 D |
From 35.00€
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Item number: Cay10004600-1
Cytokeratins (CKs) are intermediate filaments proteins and members of the cytokeratin protein family. The cytokeratin family is composed of at least 20 unique gene products, which fall into two categories: type I acidic cytokeratins, CK9-CK20, and type II neutral-basic cytokeratins, CK1-CK8. Each cytokeratin is...
Keywords: | pan-Cytokeratin |
Application: | FC, IF, IHC, WB |
Host: | Mouse |
Species reactivity: | human |
422.00€
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Item number: Cay10461-50
Paclitaxel, a potent disruptor of microtubules derived from the bark of the Pacific yew tree, is widely used as a chemotherapeutic compound. Tested against a panel of cervical (HeLa), lung (A549), breast (MCF-7), colon (HT-29), ovarian (OVG-1), and pancreatic (PC-Sh) carcinomas, paclitaxel demonstrates IC50 values...
Keywords: | NSC 125973, betaS-(benzoylamino)-alphaR-hydroxy-benzenepropanoic acid,... |
Application: | Apotosis inducer |
CAS | 33069-62-4 |
MW: | 853.9 D |
From 43.00€
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Item number: Cay10469-50
(±)7(8)-DiHDPA is a major metabolite of docosahexaenoic acid (DHA, Cay-90310) that is produced via oxidation by cytochrome P450 epoxygenases. Epoxygenase metabolites of DHA, including (±)7(8)-DiHDPA, suppress aggregation and thromboxane synthesis in isolated platelets.Formal Name:...
Keywords: | (±)7,8-dihydroxydocosa-4Z,10Z,13Z,16Z,19Z-pentaenoic acid |
CAS | 168111-93-1 |
MW: | 362.5 D |
From 108.00€
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Item number: Cay10462-50
Eicosapentaenoic acid (EPA, Cay-90110) is converted to epoxyeicosatetraenoic acids (EpETE) by several cytochrome P450 isoforms. The major product of this epoxygenase pathway, (±)17(18)-EpETE (Cay-50861), relaxes vascular and airway smooth muscle by binding large conductance Ca2+-activated K+ (BKCa) channels by...
Keywords: | (±)11,12-EEQ, (±)11,12-Epoxyeicosatetraenoic Acid, (±)11,12-epoxy-5Z,8Z,14Z,17Z- eicosatetraenoic acid |
Application: | Bioactive lipid assays |
CAS | 504435-15-8 |
MW: | 318.5 D |
From 65.00€
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Item number: Cay10464-50
Cytochrome P450 metabolism of polyunsaturated fatty acids produces numerous bioactive epoxide regioisomers. (±)13(14)-EpDPA is a docosahexaenoic acid (DHA, Cay-90310) epoxygenase metabolite, derived via epoxidation of the 13,14-double bond of DHA. It has been detected in rat brain and spinal cord and is a preferred...
Keywords: | (±)13,14-EDP, (±)13,14-EpDPE, (±)13,14-epoxy Docosapentaenoic Acid, (±)13,14-epoxy DPA,... |
Application: | Soluble epoxide hydrolase substrate |
CAS | 895127-64-7 |
MW: | 344.5 D |
From 56.00€
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Item number: Cay10465-50
Docosahexaenoic acid (DHA, Cay-90310) is the most abundant omega-3 fatty acid in neural tissues, especially in the brain and retina. (±)7(8)-EpDPA is an epoxide derivative of DHA that is generated by the action of cytochrome P450 epoxygenases. It is naturally occurring in plasma and brain and spinal cord tissues and...
Keywords: | (±)7,8-EDP, (±)7,8-EpDPE, (±)7,8-epoxy Docosapentaenoic Acid, (±)7,8-epoxy DPA,... |
Application: | Soluble epoxide hydrolase substrate |
CAS | 895127-66-9 |
MW: | 344.5 D |
From 56.00€
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Item number: Cay10466-50
(±)11(12)-DiHETE is a dihydroxy metabolite of EPA produced by cytochrome P450-mediated epoxide formation and subsequent hydrolysis by epoxide hydrolase. Plasma levels of (±)11(12)-DiHETE are increased over baseline after an oral dose of 1008 mg EPA.Formal Name: 11,12-dihydroxy-5Z,8Z,14Z,17Z-eicosatetraenoic acid....
Keywords: | 11,12-dihydroxy-5Z,8Z,14Z,17Z-eicosatetraenoic acid |
CAS | 867350-92-3 |
MW: | 336.5 D |
From 141.00€
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Item number: Cay10467-50
Eicosapentaenoic acid (EPA, Cay-90110) is an omega-3 polyunsaturated fatty acid that is abundant in marine organisms and fish oils. EPA is metabolized, in part, through cytochrome P450-catalyzed epoxidation followed by conversion to the vicinal diols by epoxide hydrolases. (±)5(6)-DiHETE is a possible metabolite...
Keywords: | (±)5,6-dihydroxy-8Z,11Z,14Z,17Z-eicosatetraenoic acid |
Application: | Metabolic studies |
CAS | 845673-97-4 |
MW: | 336.5 D |
From 141.00€
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