Dofetilide

Dofetilide
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay15045-5 5 mg -

6 - 10 business days*

84.00€
Cay15045-10 10 mg -

6 - 10 business days*

106.00€
Cay15045-25 25 mg -

6 - 10 business days*

222.00€
Cay15045-50 50 mg -

6 - 10 business days*

401.00€
 
Dofetilide is a class III antiarrhythmic agent that prolongs cardiac action potential duration by... more
Product information "Dofetilide"
Dofetilide is a class III antiarrhythmic agent that prolongs cardiac action potential duration by selectively inhibiting the rapidly activating inward rectifying component of net delayed rectifier K+ current (IC50 = 31.5 nM in guinea pig cardiomyocytes). However, at 1 µM, dofetilide has pro-arrhythmic activity, inducing early afterdepolarizations (prolonged repolarization) in cell models and Torsade de Pointes in a rabbit screen for proarrhythmic properties when administered at a dose of 10 mg/kg. Formulations containing dofetilide have been used in the treatment of highly symptomatic atrial fibrillation and the conversion of flutter to normal sinus rhythm.Formal Name: N-[4-[2-[methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]-methanesulfonamide. CAS Number: 115256-11-6. Synonyms: Tikosyn, UK 68789. Molecular Formula: C19H27N3O5S2. Formula Weight: 441.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:20): 0.4 mg/ml. lambdamax: 232 nm. SMILES: CS(NC1=CC=C(OCCN(C)CCC2=CC=C(NS(C)(=O)=O)C=C2)C=C1)(=O)=O. InChi Code: InChI=1S/C19H27N3O5S2/c1-22(13-12-16-4-6-17(7-5-16)20-28(2,23)24)14-15-27-19-10-8-18(9-11-19)21-29(3,25)26/h4-11,20-21H,12-15H2,1-3H3. InChi Key: IXTMWRCNAAVVAI-UHFFFAOYSA-N.
Keywords: Tikosyn, UK 68789, N-[4-[2-[methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]-methanesulfonamide
Supplier: Cayman Chemical
Supplier-Nr: 15045

Properties

Application: Voltage-gated potassium channel (KCNH2) blocker
MW: 441.6 D
Formula: C19H27N3O5S2
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 115256-11-6| Matching products
KEGG ID : K04905 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H302, H360, H373, H401, H411
P Phrases: P201, P202, P260, P264, P270, P273, P280, P301+310, P308+313, P314, P330, P391, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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