8 products were found matching "Cay15045"!

Dofetilide is a class III antiarrhythmic agent that prolongs cardiac action potential duration by selectively inhibiting the rapidly activating inward rectifying component of net delayed rectifier K+ current (IC50 = 31.5 nM in guinea pig cardiomyocytes). However, at 1 µM, dofetilide has pro-arrhythmic activity,...

Monastrol is a reversible, cell-permeable inhibitor of the motor protein Eg5 (kinesin family protein 11, Kif11), blocking basal ATPase activity in vitro (IC50 = 6.1 µM) and inducing the formation of monoastral spindles in cell-based assays (IC50 = 51.3 µM). It arrests cells in mitosis without targeting tubulin and,...

AM679 is a potent synthetic cannabinoid (CB) with Ki values of 13.5 and 49.5 nM for the CB1 and CB2 receptors, respectively. The physiological and toxicological properties of this compound are not known. This product is intended for research and forensic applications.Formal Name:...

Quinacrine is an acridine compound with diverse biological activities that has also been used as a stain for DNA and RNA in fixed cells and for fluorescent tracking of acidic vesicles, such as lysosomes, in live cells. It has anti-protozoal properties, potently prevents misfolding of prion protein (EC50 = 0.3 µM),...

AB-PINACA (Cay-14038) is a synthetic cannabinoid recently identified in illegal herbal products. Structurally, this designer drug is developed on an indazole base, which distinguishes it from the many JWH compounds having an indolyl base. AB-PINACA N-(4-hydroxypentyl) metabolite is expected to be a metabolite of...

Probucol is a potent antioxidant that inhibits the oxidation of cholesterol in LDL, which prevents the formation of macrophage-derived foam cells that lead to atherosclerotic vascular lesions. Probucol's use is limited, however, because it leads to the reduction of HDL cholesterol as well. Probucol inhibits up to...

Wiskott-Aldrich syndrome proteins (WASPs) regulate the actin cytoskeleton by directly interacting with actin in the Arp2/3 complex. As a result, they have essential functions in diverse cellular processes, including phagocytosis, cell motility, and membrane trafficking. Wiskostatin is a cell-permeable, selective...

Octanoyl-DL-carnitine is a medium-chain acylcarnitine. It decreases the oxidation rate of the branched-chain 2-oxo acids 3-methyl-2-butanoate and 4-methyl-2-oxopentanoate in isolated rat muscle mitochondria in the presence of carnitine, but increases it in the absence of carnitine. Octanoyl-DL-carnitine, with...