17 products were found matching "Cay14671"!

Z-VAD(OH)-FMK is an irreversible tripeptide inhibitor of all caspases. This non-methylated form is useful in studies involving recombinant, isolated, or purified enzymes. Unlike the methylated form, Z-VAD(OMe)-FMK (Cay-14463), this compound does not require pretreatment with esterases prior to in vitro use.Formal...

Sphingosine-1-phosphate (S1P) is an extracellular lipid mediator whose major effects are mediated through five distinct G protein-coupled receptors S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8. S1P4 couples to Galphai, Galphao, and Galpha12/13 proteins leading to the stimulation of MAPK/ERK...

G protein-coupled estrogen receptor (GPER), or GPR30, specifically binds natural and man-made estrogens. It is thought to be involved in estrogen-sensitive cancers. GPER knockout mice are fertile, although they exhibit thymic atrophy, impaired glucose tolerance, and altered bone growth. G-15 is a cell-permeable...

BB-22 (Cay-14099) is synthetic cannabinoid which has been identified in herbal mixtures. It is a quinolinyl cyclohexyl indole with a carboxylate group, abbreviated as QUCHIC. methyl-1-(cyclohexylmethyl)-1H-indole-3-Carboxylate is an analog of BB-22 that lacks the quinoline group. The physiological and toxicological...

PB-22 (Cay-14096) is synthetic cannabinoid which has been identified in herbal mixtures. It is a quinolinyl pentyl indole with a carboxylate group, abbreviated as QUPIC. 5-fluoro PB-22 (Cay-14095) is a derivative of PB-22 that bears a fluorine atom at the terminal carbon of the pentyl chain....

PB-22 (Cay-14096) is synthetic cannabinoid that has been identified in herbal mixtures. It is a quinolinyl pentyl indole with a carboxylate group, abbreviated as QUPIC. methy-1-pentyl-1H-indole-3-Carboxylate is an analog of PB-22 that lacks the quinoline group. The physiological and toxicological properties of this...

SET domain-containing protein 7/9 (SET7/9) is a histone methyltransferase that monomethylates lysine 4 of histone H3, which generates a specific tag for epigenetic transcriptional activation. It plays a role in the transcriptional activation of tumor suppressor p53 in response to DNA damage as well as the...

JWH 019 N-(5-hydroxyhexyl) metabolite-d5 (Cay-14687) is intended for use as an internal standard for the quantification of JWH 019 N-(5-hydroxyhexyl) metabolite (Cay-14814) by GC- or LC-MS. Cannabimimetic indoles, including certain JWH compounds, have been identified in herbal blends. JWH 018, a potent agonist of...

JWH 203 N-(4-hydroxypentyl) metabolite-d5 contains five deuterium atoms at the 2, 4 ,5, 6, and 7 positions. It is intended for use as an internal standard for the quantification of JWH 203 N-(4-hydroxypentyl) metabolite by GC- or LC-mass spectrometry. JWH 203 (Cay-9000736) is an analgesic chemical from the...

(-)-Indolactam V is a tumor-promoting teleocidin compound that activates protein kinase C (PKC). It binds to PKC regulatory domains of mouse skin PKCeta and rat brain PKCgamma with Ki values of 3.4 nM and 1 µM, respectively. At 1 µM, (-)-indolactam V induces differentiation of human embryonic stem cells into...

gamma-Secretase is a multi-subunit aspartyl protease that cleaves amyloid precursor protein (APP) and many other type 1 transmembrane proteins, including Notch, E-cadherin, and ErbB4. The proteolysis of APP by secretases produces beta amyloid (Abeta), a 39- to 42-amino acid peptide which forms the amyloid plaques...

G protein-coupled receptor 12 (GPR12) is a high affinity receptor for sphingosine-1-phosphate, sphingosyl-phosphorylcholine and tyrosol that is expressed in brain, pituitary, ovary, and testis tissues. GPR12 plays a role in neuronal differentiation, neuronal growth and the formation of synaptic contacts. Cayman's...