6 products were found matching "Cay16931"!

Desloratadine is a histamine H1 receptor antagonist (Ki = 0.97 nM) and an active metabolite of loratadine (Cay-15625). It is formed from loratadine primarily by the cytochrome P450 (CYP) isoforms CYP3A4, CYP2D6, and CYP2C19. It inhibits calcium flow in neurons and glia in vitro (IC50s = 9.177 and 0.3185 µM,...

GDC-0879 is an inhibitor of B-RafV600E (IC50 = 0.13 nM for human recombinant enzyme). It is selective for B-RafV600E over a panel of 140 kinases at a concentration of 1 µM. GDC-0879 inhibits phosphorylation of ERK in MALME-3M cells (IC50 = 63 nM) as well as phosphorylation of MEK1 in COLO 205 and A375 cells that...

beta-Boswellic acid is a pentacyclic triterpene originally isolated from Boswellia that has diverse bioactivities. It inhibits 5-lipoxygenase (5-LO) with an IC50 value of approximately 5 µM but is less potent than its derivative 3-acetyl-11-keto-beta-boswellic acid (Cay-11672). It inhibits cell proliferation in...

Ranitidine is a histamine H2 receptor antagonist. It reverses histamine-induced relaxation of isolated rat uterine horn (pA2 = 6.9) as well as histamine-induced increases in contraction frequency in isolated guinea pig right atrium (pA2 = 7.2). Ranitidine (0.03-3 mg/kg, i.v.) inhibits histamine-and...

Limonin is the first described limonoid, which are naturally occurring tetranortriterpenoids that impart bitter flavor in citrus fruits. Compounds belonging to this group have reported anti-proliferative and proapoptotic activity on several cancer cell lines as well as pesticidal, anti-malarial, anti-microbial, and...

Allopregnanolone (Cay-16930) is an analytical reference standard categorized as a GABAA and GABAC receptor positive allosteric modulator. Allopregnanolone has anxiolytic-like and anticonvulsant activities in rodents. Formulations containing allopregnanolone have been used in the treatment of postpartum depression....