Desert HedgeHog, His Tag, human recombinant (rHuDHH-His)

Desert HedgeHog, His Tag, human recombinant (rHuDHH-His)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
97385.5 5 µg - -

3 - 10 business days*

94.00€
97385.25 25 µg - -

3 - 10 business days*

208.00€
97385.1 1 mg - -

3 - 10 business days*

4,160.00€
 
Recombinant human DHH produced in E.coli is a single, non-glycosylated, polypeptide chain... more
Product information "Desert HedgeHog, His Tag, human recombinant (rHuDHH-His)"
Recombinant human DHH produced in E.coli is a single, non-glycosylated, polypeptide chain containing 197 amino acids (23-198) and having a molecular mass of 22 kDa. DHH is fused to His-tag (20 amino acids) at N-terminus. DHH is part of the Hedgehog family which encodes signaling molecules that are involved in regulating morphogenesis. DHH protein is a precursor that is autocatalytically cleaved, the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. Additionally, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the organism. Defects in DHH protein have been associated with partial gonadal dysgenesis (PGD) accompanied by minifascicular polyneuropathy. DHH plays a role both male gonadal differentiation and perineurial development. DHH plays a role in intercellular signaling which is essential for a variety of patterning events during development. DHH functions as a spermatocyte survival factor in the testes and is essential for testes development.
Keywords: HHG-3, Desert Hedgehog homolog, MGC35145, Desert hedgehog protein, DHH.
Supplier: Biomol GmbH
Supplier-Nr: 97385

Properties

Application: Bioassay
Conjugate: No
Host: E.coli
Species reactivity: human
MW: 22000 D
Format: Purified

Database Information

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: °C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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