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Product information "DNA Base Excision Repair Pathway Inhibitor"
Apurinic/apyrimidinic endonuclease-1 (Ape-1) is involved in base excision repair, cleaving the phosphodiester linkage that is 5' to the abasic site to produce a single strand break. DNA base excision repair pathway inhibitor is a cell-permeable inhibitor of Ape-1 (IC50 = 3-11 µM). Although not toxic to cells by itself at 200 µM, it enhances the cytotoxicity of certain DNA alkylating agents, including temozolomide, when added at this concentration. DNA base excision repair pathway inhibitor has little or no effect on radiation-induced cell survival.Formal Name: 7-nitro-1H-indole-2-carboxylic acid. CAS Number: 6960-45-8. Synonyms: CRT0044876, 7-Nitroindole-2-Carboxylic Acid, NSC 69877. Molecular Formula: C9H6N2O4. Formula Weight: 206.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO: 5 mg/ml, DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml, Ethanol: 0.2 mg/ml. lambdamax: 222, 243, 358 nm. SMILES: OC(C1=CC2=CC=CC([N+]([O-])=O)=C2N1)=O. InChi Code: InChI=1S/C9H6N2O4/c12-9(13)6-4-5-2-1-3-7(11(14)15)8(5)10-6/h1-4,10H,(H,12,13). InChi Key: BIUCOFQROHIAEO-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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