DNA Base Excision Repair Pathway Inhibitor

DNA Base Excision Repair Pathway Inhibitor
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay16348-10 10 mg -

6 - 10 business days*

60.00€
Cay16348-25 25 mg -

6 - 10 business days*

92.00€
Cay16348-50 50 mg -

6 - 10 business days*

130.00€
Cay16348-100 100 mg -

6 - 10 business days*

175.00€
 
Apurinic/apyrimidinic endonuclease-1 (Ape-1) is involved in base excision repair, cleaving the... more
Product information "DNA Base Excision Repair Pathway Inhibitor"
Apurinic/apyrimidinic endonuclease-1 (Ape-1) is involved in base excision repair, cleaving the phosphodiester linkage that is 5' to the abasic site to produce a single strand break. DNA base excision repair pathway inhibitor is a cell-permeable inhibitor of Ape-1 (IC50 = 3-11 µM). Although not toxic to cells by itself at 200 µM, it enhances the cytotoxicity of certain DNA alkylating agents, including temozolomide, when added at this concentration. DNA base excision repair pathway inhibitor has little or no effect on radiation-induced cell survival.Formal Name: 7-nitro-1H-indole-2-carboxylic acid. CAS Number: 6960-45-8. Synonyms: CRT0044876, 7-Nitroindole-2-Carboxylic Acid, NSC 69877. Molecular Formula: C9H6N2O4. Formula Weight: 206.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO: 5 mg/ml, DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml, Ethanol: 0.2 mg/ml. lambdamax: 222, 243, 358 nm. SMILES: OC(C1=CC2=CC=CC([N+]([O-])=O)=C2N1)=O. InChi Code: InChI=1S/C9H6N2O4/c12-9(13)6-4-5-2-1-3-7(11(14)15)8(5)10-6/h1-4,10H,(H,12,13). InChi Key: BIUCOFQROHIAEO-UHFFFAOYSA-N.
Keywords: 7-Nitroindole-2-Carboxylic Acid, CRT0044876, NSC 69877, 7-nitro-1H-indole-2-carboxylic acid
Supplier: Cayman Chemical
Supplier-Nr: 16348

Properties

Application: Cell-permeable Ape-1 inhibitor
MW: 206.2 D
Formula: C9H6N2O4
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 6960-45-8| Matching products
KEGG ID : K10771 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H315, H319, H334, H335
P Phrases: P261, P264, P271, P280, P284, P302+352, P304+340, P304+341, P305+351+338, P312, P321, P332+313, P337+313, P342+311, P362+364, P403+233, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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