- Search results for Cay17501
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8 products were found matching "Cay17501"!
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Item number: Cay17501-1
Cytosporone B is a naturally occurring agonist for the nuclear receptor Nur77 (IC50 = 0.278 nM). Activation of Nur77 with cytosporone B induces the expression of Nur77-dependent genes, including the gene for Nur77 itself. Signaling through Nur77 induces apoptosis in cancer cells and retards xenograft tumor growth....
Keywords: | Csn-B, Dothiorelone G, 3,5-dihydroxy-2-(1-oxooctyl)-benzeneacetic acid, ethyl ester |
Application: | Nur77 agonist |
CAS | 321661-62-5 |
MW: | 322.4 D |
From 43.00€
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Item number: Cay17750-1
BHPI is an antagonist of estrogen receptor alpha (ERalpha) that blocks 17beta-estradiol-induced proliferation of drug-resistant breast, endometrial, and ovarian cancer cell lines at concentrations ranging from 10 to 1,000 nM. It is effective in vivo, driving tumor regression in mice bearing MCF-7 xenografts at a...
Keywords: | 1,3-dihydro-3,3-bis(4-hydroxyphenyl)-7-methyl-2H-indol-2-one |
Application: | ERalpha antagonist |
CAS | 56632-39-4 |
MW: | 331.4 D |
From 77.00€
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Item number: Cay17506-1
JWH 307 (Cay-10797) is a (1-naphthoyl)pyrrole cannabimimetic that potently activates both the central cannabinoid (CB) receptor, CB1, and the peripheral CB2 receptor (Ki = 7.7 and 3.3 nM, respectively). JWH 307 3'-isomer differs from JWH 307 by having the fluorophenyl group at the 3' position, rather than the 2'...
Keywords: | [4-(2-fluorophenyl)-1-pentyl-1H-pyrrol-3-yl]-1-naphthalenyl-methanone |
Application: | Analytical reference standard, Synthetic cannabinoid derivative |
CAS | 2748622-89-9 |
MW: | 385.5 D |
From 266.00€
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Item number: Cay17502-1
Ataxia-telangiectasia mutated (ATM) is a serine/threonine kinase that activates checkpoint signaling following double strand DNA breaks and genotoxic stress. Ku-60019 is a potent, reversible inhibitor of ATM kinase (IC50 = 6.3 nM), blocking the phosphorylation of ATM substrate proteins. It is much less effective or...
Keywords: | rel-2R,6S-dimethyl-N-[5-[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl]-4-morpholineacetamide |
Application: | ATM kinase inhibitor |
CAS | 925701-46-8 |
MW: | 547.7 D |
From 39.00€
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Item number: Cay17505-1
BMS 754807 is a reversible, orally bioavailable dual inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (InsR) tyrosine kinases (IC50s = 1.8 and 1.7 nM, respectively). It has minimal effect against an array of other tyrosine and serine/threonine kinases. BMS 754807 inhibits cell...
Keywords: | 1-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]-N-(6-fluoro-3-pyridinyl)-2-methyl-(2S)-2-pyr... |
Application: | IGF-1R / InsR inhibitor |
CAS | 1001350-96-4 |
MW: | 461.5 D |
From 60.00€
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Item number: Cay17503-1
The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis. BGP-15 is a PARP inhibitor and insulin sensitizer. In perfused heart, it blocks self-ADP-ribosylation of nuclear PARP (Ki = 57 µM) and mono-ADP-ribosylation of GRP78, resulting in decreased levels of reactive...
Keywords: | N-[2-hydroxy-3-(1-piperidinyl)propoxy]-3-pyridinecarboximidamide, dihydrochloride |
Application: | PARP inhibitor, Insulin sensitizer |
CAS | 66611-37-8 |
MW: | 351.3 D |
From 50.00€
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Item number: Cay17507-1
Lipoprotein-associated phospholipase A2, also known as platelet activating factor acetylhydrolase (PAF-AH) or phospholipase A2 group 7, hydrolyzes glycerophospholipids to produce lyso-PAF/lyso-phosphatidylcholine and short and/or oxidized fatty acids, many of which have pro-inflammatory or pro-oxidative activities....
Keywords: | (2R,6R)-rel-2-[4-(1,1-dimethylethyl)phenyl]-1,2,5,6-tetrahydro-6-(4-methylphenyl)-1-[(4-methylphenyl)sulfonyl]-3-pyridinec... |
Application: | PAF-AH1b2/3 inhibitor |
CAS | 942285-55-4 |
MW: | 503.7 D |
From 43.00€
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Item number: Cay17509-1
Polmacoxib is an inhibitor of cyclooxygenase 2 (COX-2) and the carbonic anhydrase subtypes I (CAI) and CAII. It inhibits COX-2 in the absence of carbonic anhydrase II with an IC50 value of 40 nM, which increases by approximately 4- and 17-fold in the presence of a CAII at a molar ratio of 1:1 and 1:5, respectively....
Keywords: | 4-[3-(3-fluorophenyl)-4,5-dihydro-5,5-dimethyl-4-oxo-2-furanyl]-benzenesulfonamide |
Application: | COX-2 inhibitor |
CAS | 301692-76-2 |
MW: | 361.4 D |
From 77.00€
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