Curcumin

Curcumin is the major yellow pigment in turmeric and curry and has antioxidant, anti-inflammatory, and antitumor activities. It inhibits nitric oxide (NO) production (IC50 = 6 µM) and reduces inducible nitric oxide synthase (iNOS) activity in LPS-stimulated RAW 264.7 cells. Curcumin inhibits release of histamine and the inflammatory cytokines TNF-alpha, IL-1beta, IL-6, and IL-8 from HMC-1 mast cells. In vivo, curcumin decreases serum levels of histamine and TNF-alpha, inhibits histopathological changes of nasal mucosa, and decreases the number of sneezes and nasal rubbing in a mouse model of ovalbumin-induced rhinitis. Curcumin (100 or 200 mg/kg) prevents ovalbumin-induced accumulation of 3-nitrotyrosine (3-NT), a marker of oxidative stress, in mouse heart. Topical administration of curcumin (1-10 µmol) reduces the number of tumors induced by phorbol 12-myristate 13-acetate (TPA, Cay-10008014) in mouse skin. Dietary administration of curcumin reduces the number of tongue neoplasms and preneoplastic lesions induced by 4-nitroquinoline 1-oxide (4-NQO) in rats.Formal Name: 1,7-bis(4-hydroxy-3-methoxyphenyl)-1E,6E-heptadiene-3,5-dione. CAS Number: 458-37-7. Synonyms: Indian Saffron, Turmeric yellow. Molecular Formula: C21H20O6. Formula Weight: 368.4. Purity: >90%. Formulation: (Request formulation change), A crystalline solid. Solubility: 0.1 M NaOH: 3 mg/ml, 10 mM Na2CO3: 50 µg/ml, Acetone: 20 mg/ml, Acetone:10 mM Na2CO3 (50:50): 5 mg/ml, Water: 100 µg/ml. lambdamax: 427 nm. SMILES: COc1cc(/C=C\C(=O)CC(=O)\C=C/c2ccc(O)c(OC)c2)ccc1O. InChi Code: InChI=1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+. InChi Key: VFLDPWHFBUODDF-FCXRPNKRSA-N. Origin: Plant/Turmeric.