9 products were found matching "Cay11730"!

Coumestrol is a phytoestrogen that occurs naturally in soybeans, spinach, and clover. It competitively (vs. 17beta-estradiol, Cay-10006315) binds the estrogen receptors ERalpha (IC50 = 11 nM) and ERbeta (IC50 = 2 nM) and can induce ER-dependent gene expression in isolated cells. Coumestrol is also a weak antagonist...

Liproxstatin-1 is a ferroptosis inhibitor. It inhibits ferroptotic cell death (IC50 = 22 nM) and lipid peroxidation in mouse embryonic fibroblasts (MEFs) with an inducible knockdown of glutathione peroxidase 4 (Gpx4-/- MEFs) when used at a concentration of 50 nM. Liproxstatin-1 also inhibits ferroptosis induced by...

RS 504393 is a selective antagonist of the MCP-1 receptor CCR2 (IC50s = 89 nM and >100 µM for CCR2 and CCR1, respectively). It has been shown to inhibit MCP-1-stimulated chemotaxis (IC50 = 330 nM) and ischemia-reperfusion injury in kidneys.Formal Name:...

5-methoxy DET is a synthetic tryptamine designer drug structurally similar to the potent hallucinogen N,N-DMT (Cay-13959). It inhibits serotonin uptake with an IC50 value of 2.4 µM and activates 5-HT2A receptors with an EC50 value of 8.11 nM. This product is intended for forensic and research applications.Formal...

Bosentan is an antagonist of the endothelin receptors type A (Ki = 6.5 nM) and type B (Ki = 340 nM).Formal Name: 4-(1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-benzenesulfonamide. CAS Number: 147536-97-8. Synonyms: Ro 47-0203. Molecular Formula: C27H29N5O6S. Formula Weight:...

Benzocyclidine (BCP) is a derivative of phencyclidine with a benzothiophenyl group instead of a phenyl ring. It acts as a potent and selective dopamine reuptake inhibitor (IC50 = 8 nM) with negligible affinity for the NMDA receptor-linked phencyclidine receptor (K0.5 = 6 µM). BCP has been used to label the dopamine...

O6-Methylguanine-DNA methyltransferase (MGMT) (Cay-11176) is a DNA repair protein which removes an alkyl group from the O6 position on guanine in an autoinactivating reaction. Although important in normal DNA repair, this reaction confers resistance to treatments that use O6-alkylating agents to produce...

LY320135 is a selective cannabinoid (CB) receptor 1 antagonist (Kis = 224 and >10,000 nM for CB1 and CB2, respectively, in vitro). It is selective for CB1 over alpha1- and alpha2- adrenergic, D1 and D2 dopamine, benzodiazepine, histamine H1, GABA, serotonin (5-HT), and muscarinic receptors. It reverses the...

Makisterone A is an ecdysteroid that drives molting in insects. It binds the heterodimeric ecdysone receptor with nanomolar affinity.Formal Name: (2beta,3beta,5beta,22R,24R)-2,3,14,20,22,25-hexahydroxy-ergost-7-en-6-one. CAS Number: 20137-14-8. Molecular Formula: C28H46O7. Formula Weight: 494.7. Purity: >95%....