Ciglitazone

Ciglitazone is an antidiabetic drug of the thiazolidinedione structural class. Ciglitazone is a potent and selective PPARgamma ligand. It binds to the PPARgamma ligand-binding domain with an EC50 of 3.0 µM. Ciglitazone is active in vivo as an anti-hyperglycemic agent in the ob/ob mouse model.Formal Name: 5-[[4-[(1-methylcyclohexyl)methoxy]phenyl]methyl]-2,4-thiazolidinedione. CAS Number: 74772-77-3. Synonyms: ADD 3878, U-63287. Molecular Formula: C18H23NO3S. Formula Weight: 333.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 16 mg/ml, DMSO: 21 mg/ml, DMSO:PBS (pH 7.2) (1:4): 400 µg/ml, Ethanol: 29 mg/ml. lambdamax: 228, 279, 284 nm. SMILES: O=C1NC(=O)C(S1)Cc1ccc(cc1)OCC1(C)CCCCC1. InChi Code: InChI=1S/C18H23NO3S/c1-18(9-3-2-4-10-18)12-22-14-7-5-13(6-8-14)11-15-16(20)19-17(21)23-15/h5-8,15H,2-4,9-12H2,1H3,(H,19,20,21). InChi Key: YZFWTZACSRHJQD-UHFFFAOYSA-N.