Chelerythrine (chloride)

Chelerythrine (chloride)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay11314-1 1 mg -

6 - 10 business days*

43.00€
Cay11314-5 5 mg -

6 - 10 business days*

85.00€
Cay11314-10 10 mg -

6 - 10 business days*

146.00€
Cay11314-25 25 mg -

6 - 10 business days*

255.00€
 
Chelerythrine is a potent, cell permeable inhibitor of protein kinase C (IC50 = 660 nM) that does... more
Product information "Chelerythrine (chloride)"
Chelerythrine is a potent, cell permeable inhibitor of protein kinase C (IC50 = 660 nM) that does not inhibit tyrosine protein kinases, cAMP-dependent protein kinase, or calcium/calmodulin-dependent protein kinase. Chelerythrine also inhibits Bcl-xL function (IC50 = 1.5 µM) by displacing Bax binding, inducing apoptosis in several cancer cell lines. Chelerythrine can also have PKC-independent effects, activate p38 MAP kinase and JUNK signaling pathways, and induce apoptosis in cancer cells both in vitro and in vivo.Formal Name: 1,2-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridinium, monochloride. CAS Number: 3895-92-9. Synonyms: Broussonpapyrine chloride, NSC 646662. Molecular Formula: C21H18NO4 . Cl. Formula Weight: 383.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 0.25 mg/ml. lambdamax: 212, 271, 320, 398 nm. SMILES: COC1=CC=C2C(C=[N+](C)C3=C(C=C(OCO4)C4=C5)C5=CC=C32)=C1OC.[Cl-]. InChi Code: InChI=1S/C21H18NO4.ClH/c1-22-10-16-13(6-7-17(23-2)21(16)24-3)14-5-4-12-8-18-19(26-11-25-18)9-15(12)20(14)22,/h4-10H,11H2,1-3H3,1H/q+1,/p-1. InChi Key: WEEFNMFMNMASJY-UHFFFAOYSA-M.
Keywords: Broussonpapyrine chloride, NSC 646662, 1,2-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridinium, monochloride
Supplier: Cayman Chemical
Supplier-Nr: 11314

Properties

Application: Inhibitor of protein kinase C
MW: 383.8 D
Formula: C21H18NO4 . Cl
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 3895-92-9| Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H302, H312, H315, H319, H332, H335
P Phrases: P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P361+364, P362+364, P403+233, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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