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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABD-22850 | 1 kit (100 assays) | - |
3 - 8 business days* |
418.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Our Cell Meter(TM) assay kits are a set of tools for monitoring cellular functions. In the... more
Product information "Cell Meter(TM) Live Cell Caspase 3/7 and Phosphatidylserine Detection Kit"
Our Cell Meter(TM) assay kits are a set of tools for monitoring cellular functions. In the process of apoptosis, one of key events is the activation of caspases. The activation of caspase 3/7 is an important for the initiation of apoptosis. It has been proven that caspase 3/7 has substrate selectivity for the peptide sequence Asp-Glu-Val-Asp (DEVD). This kit uses SR-DEVD-FMK as a fluorescent indicator to detect caspase 3/7 activities. SR-DEVD-FMK is cell permeable and nontoxic, once bound to caspases, the fluorescent reagent is retained inside the cell. The binding event prevents the caspases from further catalysis but will not stop apoptosis from proceeding. SR-DEVD-FMK is a red label reagent with Ex/Em = 550/595 nm. Annexins are a family of proteins that bind to phospholipid membranes in the presence of calcium. Annexin V is used to detect apoptotic cells that express phosphatidylserine (PS) on the cell surface. The appearance of PS on the cell surface is a universal indicator of the initial/intermediate stages of cell apoptosis. Annexin V-dye conjugates monitor cell apoptosis through measuring the translocation of PS. The Annexin V-iFluor 488(TM) used in this kit is a green labeling reagent, with Ex/Em = 490/525 nm. The kit is designed to detect apoptosis by simultaneously monitoring Caspase 3/7 and Annexin V activities in mammalian cells. The kit also provides a Hoechst dye for labeling the nucleus of the whole population of the cells, and propidium iodide dye for staining necrosis cells. This kit is applicable for fluorescence microscope, flow cytometer, and fluorescence microplate reader. The kit provides all the essential components with an optimized assay protocol.
Supplier: | AAT Bioquest |
Supplier-Nr: | 22850 |
Properties
Application: | Caspase 3/7 and phosphatidylserine detection |
Format: | Homog. |
Database Information
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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