Caylin-2

Caylin-2
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10005002-1 1 mg -

6 - 10 business days*

104.00€
Cay10005002-5 5 mg -

6 - 10 business days*

385.00€
Cay10005002-10 10 mg -

6 - 10 business days*

718.00€
 
Nutlin-3 is an activator of p53 that functions by inhibiting the interaction of p53 with MDM2, a... more
Product information "Caylin-2"
Nutlin-3 is an activator of p53 that functions by inhibiting the interaction of p53 with MDM2, a negative regulator of p53 activity. Caylin-2 is a nutlin-3 analog in which trifluoromethyl groups have been substituted for chlorine on the 2 phenyl rings. At high concentrations, caylin-2 inhibits the growth of HCT116 cells with an IC50 of approximately 8 µM, making it about 10-fold less potent than nutlin-3. Interestingly, at concentrations between 5-100 nM, caylin-2 promotes the growth of HCT116 cells approximately 40% compared to untreated cells. The mechanism of the growth promoting properties of caylin-2 have not yet been elucidated.Formal Name: 4-[4,5-bis(4-trifluoromethyl-phenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carboxyl]-piperazin-2-one. CAS Number: 1392830-09-9. Molecular Formula: C32H30F6N4O4. Formula Weight: 648.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 50 mg/ml, Ethanol:PBS (pH 7.2)(1:3): .025 mg/ml. SMILES: COc1ccc(c(OC(C)C)c1)C1=N[C@@H](c2ccc(c(c2)C(F)(F)F)C(F)(F)F)[C@@H](c2cccc(c2)C(F)(F)F)N1C(=O)N1CCNC(=O)C1. InChi Code: InChI=1S/C32H30F6N4O4/c1-18(2)46-25-16-23(45-3)12-13-24(25)29-40-27(19-4-8-21(9-5-19)31(33,34)35)28(20-6-10-22(11-7-20)32(36,37)38)42(29)30(44)41-15-14-39-26(43)17-41/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,39,43)/t27-,28+/m0/s1. InChi Key: HXLGOAAYXPLLCI-WUFINQPMSA-N.
Keywords: 4-[4,5-bis(4-trifluoromethyl-phenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carboxyl]-piperazin-2-one
Supplier: Cayman Chemical
Supplier-Nr: 10005002

Properties

Application: Nutlin-3 analog
MW: 648.6 D
Formula: C32H30F6N4O4
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 1392830-09-9| Matching products
KEGG ID : K06643 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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