Catharanthine

Catharanthine
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay11695-50 50 mg -

6 - 10 business days*

52.00€
Cay11695-100 100 mg -

6 - 10 business days*

96.00€
Cay11695-500 500 mg -

6 - 10 business days*

442.00€
 
Catharanthine is an indole alkaloid that has been found in C. roseus and has diverse biological... more
Product information "Catharanthine"
Catharanthine is an indole alkaloid that has been found in C. roseus and has diverse biological activities. It is a precursor in the biosynthesis of the antimitotic agents vinblastine (Cay-11762) and vincristine (Cay-11764). Catharanthine (320 µM) inhibits microtubule assembly and the proliferation of HCT116 colon cancer cells (IC50 = 60 µg/ml). It induces the release of amylase from mouse pancreas preparations when used at a concentration of 100 µM. Catharanthine (0.5-20 mg/kg) decreases blood pressure and heart rate in anesthetized normotensive rats.Formal Name: (2alpha,5beta,6alpha)-3,4-didehydro-ibogamine-18beta-carboxylic acid, methyl ester, 2R,3R-dihydroxybutanedioate (2:1). CAS Number: 4168-17-6. Synonyms: (+)-3,4-Didehydrocoronaridine. Molecular Formula: C21H24N2O2 . 1/2C4H6O6. Formula Weight: 486.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml. lambdamax: 224, 283 nm. SMILES: CCC1=C[C@H]2C[C@]([C@]1([H])[N@@](C2)CC3)(C(OC)=O)C4=C3C5=C(N4)C=CC=C5.OC([C@@H]([C@@H](O)C(O)=O)O)=O.CCC6=C[C@H]7C[C@]([C@]6([H])[N@@](C7)CC8)(C(OC)=O)C9=C8C%10=C(N9)C=CC=C%10. InChi Code: InChI=1S/2C21H24N2O2.C4H6O6/c2*1-3-14-10-13-11-21(20(24)25-2)18-16(8-9-23(12-13)19(14)21)15-6-4-5-7-17(15)22-18,5-1(3(7)8)2(6)4(9)10/h2*4-7,10,13,19,22H,3,8-9,11-12H2,1-2H3,1-2,5-6H,(H,7,8)(H,9,10)/t2*13-,19+,21-,1-,2-/m001/s1. InChi Key: OXIDCVCPXUNSCI-DWGLLIDUSA-N. Origin: Plant/Vinca rosea.
Keywords: (+)-3,4-Didehydrocoronaridine, (2alpha,5beta,6alpha)-3,4-didehydro-ibogamine-18beta-carboxylic acid, methyl ester
Supplier: Cayman Chemical
Supplier-Nr: 11695

Properties

Application: Vinblastine and vincristine precursor, Cancer studies
MW: 336.4 D
Formula: C21H24N2O2 . 1/2C4H6O6
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 4168-17-6| Matching products
KEGG ID : K07375 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H302
P Phrases: P264, P270, P330, P301+P310, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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