13 products were found matching "Cay11695"!

Catharanthine is an indole alkaloid that has been found in C. roseus and has diverse biological activities. It is a precursor in the biosynthesis of the antimitotic agents vinblastine (Cay-11762) and vincristine (Cay-11764). Catharanthine (320 µM) inhibits microtubule assembly and the proliferation of HCT116 colon...

2-Amino-5-fluorobenzoic acid is a toxic antimetabolite for the tryptophan pathway in yeast that can be used to counterselect for TRP1, a commonly used genetic marker in S. cerevisiae. Because this trp1 strain lacks the enzymes required for the conversion of anthranilic acid to tryptophan, it is resistant to...

BIX02189 is a potent inhibitor of both MEK5 and ERK5 (IC50s = 1.5 and 59 nM, respectively), preventing transcriptional activation of the downstream target MEF2C. It minimally inhibits a panel of related kinases, including MEK1/2 and ERK1/2. BIX02189 blocks sorbitol-induced phosphorylation of ERK5, without affecting...

12-Deoxywithastramonolide is a withanolide found in W. somnifera roots. It has anti-inflammatory activity, reducing Tnf-alpha and increasing Il-10 production in mice following oral administration at doses ranging from 50-200 mg/kg. 12-Deoxywithastramonolide also reduces the growth of A549 lung and HT-29 colorectal...

Fluprostenol isopropyl ester (Cay-16769) is a potent F-series prostaglandin receptor agonist prodrug that finds clinical use as an ocular hypotensive agent for the treatment of glaucoma. 13,14-epoxy Fluprostenol isopropyl ester (Cay-13679) is an impurity generated in the production of fluprostenol isopropyl ester....

Applications: This proprietary dye can be used in prompt fluorescent detection, microplate applications, flow cytometry, and protein microarrays. Because its absorption and emission profile is similar to Cy5, it can be used in many of the same applications, however, it is 200 times brighter. Structural...

17-trans PGF3alpha is a double bond isomer of PGF3alpha and a potential metabolite of trans dietary fatty acids. There are no published reports on the biological activity of this compound.Formal Name: 9alpha,11alpha,15S-trihydroxy-prosta-5Z,13E,17E-trien-1-oic acid. CAS Number: 211100-24-2. Synonyms: 17-trans...

The peroxisome proliferator-activated receptor alpha (PPARalpha) is a nuclear receptor that regulates the expression of genes involved in fatty acid metabolism, lipoprotein synthesis and metabolism, and inflammation. GW 6471 is an antagonist of PPARalpha (IC50 = 240 nM). It drives the displacement of coactivators...

K145 is a selective inhibitor of sphingosine kinase 2 (SPHK2, Ki = 6.4 µM) with IC50 values of 4.3 and >10 µM for human recombinant SPHK2 and SPHK1, respectively. It inhibits SPHK2, but not SPHK1, activity in U937 cells when used at a concentration of 10 µM. In vivo, K145 (15 mg/kg, i.p.) inhibits tumor growth in a...

beta-Boswellic acid is a pentacyclic triterpene originally isolated from Boswellia that has diverse bioactivities. It inhibits 5-lipoxygenase (5-LO) with an IC50 value of approximately 5 µM but is less potent than its derivative 3-acetyl-11-keto-beta-boswellic acid (Cay-11672). It inhibits cell proliferation in...

alpha-Boswellic acid is a pentacyclic triterpene and an isomer of beta-boswellic acid (Cay-11693) originally isolated from B. serrata. It increases Survivin and Reelin expression, decreases production of reactive oxygen species (ROS) and levels of hyperphosphorylated Tau, and inhibits apoptosis induced by...

(+)-Etomoxir is an irreversible inhibitor of carnitine palmitoyltransferase 1 (CPT1), an enzyme that combines fatty acyl-CoAs with carnitine for transport into the mitochondria for beta-oxidation. It inhibits fatty acid oxidation in hepatocytes in vitro (IC50s = 0.1, 1, and 10 µM for human, guinea pig, and rat...