Calphostin C

Dark red to brown solid. Soluble in ethanol, methanol, DMSO or dimethylformamide. Poorly soluble in water. Potent and highly specific cell permeable protein kinase C (PKC) inhibitor. The inhibition of PKC is light-dependent, PKA, PKG, DAG kinase, phospholipase D1 and D2, myosin light chain kinase and c-Src inhibitor, Anticancer compound. Inhibits cell proliferation and strongly induces apoptosis in vitro, Inducer of endoplasmic reticulum ER-stress, Shown to directly and potently block L-type Ca channels, Calphostin C specifically inhibits contraction-stimulated glucose transport but not insulin-stimulated glucose transport in skeletal muscle, Wnt/beta-catenin/lef-1 signaling inhibitor. beta-catenin/TCF antagonist. Inhibits Wnt-activated genes in a dose-dependent fashion