10 products were found matching "AG-45A-0042EK-KI01"!

IL-37 (IL-1F7) belongs to the IL-1 family. It binds to interleukin-18 receptor (IL-18R) but not to IL-1 receptor. It was shown to play an important role as a link between innate and adaptive immunity and it is suggested as a new player in the inflammatory and immune responses mediated by the IL-18/IL-18R axis. It...

Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin). Irisin is cleaved from the...

Detection Type: Colorimetric. Assay Type: Sandwich. Sample Type: Cell Culture Supernatant, Serum. Sensitivity: 40pg/ml. Range: 0.063 to 4ng/ml. Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating...

Detection Type: Colorimetric. Assay Type: Sandwich. Sample Type: Cell Culture Supernatant, Plasma, Serum. Sensitivity: 50pg/ml. Range: 0.125 to 8ng/ml. Adiponectin [ACRP30, AdipoQ] is a promising biomarker of insulin resistance and type 2 diabetes mellitus (T2DM) but also as a potential target for management of the...

The Notch signaling pathway is essential for appropriate cell differentiation and cell fate decisions. DLK1 (Protein delta homolog 1, Preadipocyte factor 1, Pref-1) is a regulator of adipocyte differentiation found in serum and urine. DLK1 might be a decoy ligand. Serum or plasma levels of soluble DLK1 affect...

Retinol binding protein 4 (RBP4, RBP) is a 21kDa secreted protein, a member of the lipocalin family and is known as the primary transporter of retinol (vitamin A) to tissues. A recent report revealed RBP4 as an adipokine linking glucose transporter 4 (GLUT4) suppression in adipose tissue to insulin. Elevated human...

Detection Type: Colorimetric. Assay Type: Sandwich. Sample Type: Cell Culture Supernatant, Plasma, Serum. Sensitivity: 75pg/ml. Range: 0.156 to 10ng/ml. Seven proteins containing an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain, both characteristics of angiopoietins, have been identified and...

Resistin (FIZZ3, ADSF, Adipose tissue-specific secretory factor) is a 12.5kDa cysteine-rich adipocytokine. In rodents, increased resistin-levels impair insulin action, while genetic ablation or down-regulation of the resistin gene improves insulin sensitivity. In humans most reports identified inflammatory cells and...

Glutathione peroxidase 3 (GPX3, GSHPX3) is a selenium-dependent extracellular enzyme, protecting cells and enzymes from oxidative damage by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxides. GPX3 is involved in inflammatory bowel disease, in asthma and in diabetes. The...

Sirtuins (Silent information regulators, SIRTs) deacetylate and/or ADP-ribosylate lysine residues of target proteins in an NAD+-dependent manner. Sirtuins are critical regulators of many cellular processes, including insulin secretion, the cell cycle and apoptosis. Sirtuins, in particular SIRT1, emerged as critical...