4 products were found matching "029448.10"!

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Item number: Cay29440-10

Bropirimine is an immunomodulator with diverse biological activities. It is a toll-like receptor 7 (TLR7) agonist that inhibits RANKL-induced osteoclast differentiation of murine bone marrow-derived macrophages (BMDMs) in a concentration-dependent manner, an effect that is reversed by an anti-IFN-beta antibody....

Keywords:	ABPP, NSC 149027, PNU 54461, U-54461, 2-amino-5-bromo-6-phenyl-4(3H)-pyrimidinone
Application:	Immunomodulator, TLR7 agonist
CAS	56741-95-8
MW:	266.1 D

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Drotaverine (hydrochloride)

Item number: Cay20944-10

Drotaverine is an alkaloid that has been described as an inhibitor of phosphodiesterase 4 and negative allosteric modulator of L-type Ca2+ channels.Formal Name: 1-[(3,4-diethoxyphenyl)methylene]-6,7-diethoxy-1,2,3,4-tetrahydro-isoquinoline, monohydrochloride. CAS Number: 985-12-6. Molecular Formula: C24H31NO4 . HCl....

Keywords:	1-[(3,4-diethoxyphenyl)methylene]-6,7-diethoxy-1,2,3,4-tetrahydro-isoquinoline, monohydrochloride
Application:	PDE4 inhibitor
CAS	985-12-6
MW:	434 D

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SCIO 469

Item number: Cay29484-10

SCIO 469 is a p38 MAPK inhibitor (IC50 = 9 nM for p38alpha). It is 10-fold selective for p38alpha over p38beta MAPK and 2,000-fold selective over a panel of 20 additional kinases. SCIO 469 inhibits secretion of IL-6 from multiple myeloma patient-derived bone marrow stromal cells (BMSCs) in a concentration-dependent...

Keywords:	Talmapimod,...
Application:	p38 MAPK inhibitor
CAS	309913-83-5
MW:	513 D

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Barnidipine (hydrochloride)

Item number: Cay20448-10

Barnidipine is a dihydropyridine calcium channel blocker that has an IC50 value of 0.35 nM in potassium-induced tonic contraction of pig coronary artery. It demonstrates antihypertensive activity by reducing peripheral vascular resistance. It decreases blood pressure in spontaneously hypertensive rats when...

Keywords:	YM-09730-5, (4S)-3,5-pyridinedicarboxylic acid, 3-methyl 5-[(3S)-1-(phenylmethyl)-3-pyrrolidinyl] ester, monohydrochloride
Application:	Calcium channel blocker
CAS	104757-53-1
MW:	528 D

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