11 products were found matching "Cay10004884"!

Phospholipase A2 (PLA2) catalyzes the hydrolysis of phospholipids at the sn-2 position yielding a free fatty acid and a lysophospholipid. The release of arachidonic acid from membrane phospholipids by PLA2 is believed to be a key step in the control of eicosanoid production within the cell. Mammalian tissues contain...

Peroxisome proliferator-activated receptor gamma (PPARgamma) isoforms heterodimerize with retinoic X receptors to modulate gene expression related to adipocyte differentiation, fatty acid uptake and storage, and glucose metabolism. Natural agonists of PPARgamma include fatty acids (e.g., linoleic acid and...

Prostaglandin D2 (PGD2) elicits its biological function through interaction with two distinct G protein-coupled receptors, DP1 and CRTH2/DP2. CRTH2 primarily couples to Gi or Gq subunits to mobilize Ca2+, induce cell migration, and up-regulate adhesion molecules. CRTH2 mRNA has been detected in various tissues...

Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. 16-HETE is a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation that demonstrates stereospecific biological activity. 16(S)-HETE inhibits proximal tubule ATPase...

Eicosapentaenoic acid (EPA) ethyl ester is an esterified form of the omega-3 fatty acid EPA (Cay-90110, Cay-90110.1, Cay-21908). Dietary administration of EPA ethyl ester (41.4 g/100 g of total dietary fatty acids) increases the ex vivo activity of hepatic beta-oxidation enzymes. It also reduces total hepatic...

NESS 0327 is an extremely potent cannabinoid (CB) receptor antagonist with high selectivity for the CB1 receptor compared to the CB2 receptor with Ki values of 0.35 pM and 21 nM, respectively. It is a much more potent antagonist and more selective for the CB1 receptor compared to SR 141716A (rimonabant). At nM...

Formulation: 100 µl of goat anti-rabbit HRP-conjugated secondary antibody. Origin: Animal/Bovine, Animal/Goat.

Formulation: 120 µl (10X) specific competitor double stranded (dsDNA) oligonucleotides containing the CREB DNA binding sequence.

5-Lipoxygenase (5-LO) catalyzes the biosynthesis of leukotrienes, which are involved in a variety of inflammatory responses, including neutrophil chemotaxis, vascular permeability, and smooth muscle contraction. CAY10649 is a thiazolinone compound that demonstrates direct inhibition of 5-lipoxygenase (5-LO) product...

Atractyloside is a natural heteroglucoside produced in some plants, including A. gummifera. Atractyloside prevents mitochondrial ATP synthesis by inhibiting ADP/ATP translocases, which are responsible for the exchange of adenine di- and triphosphates across the inner mitochondrial membrane.Formal Name:...