CHIR99021

CHIR99021
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay13122-1 1 mg -

6 - 10 business days*

43.00€
Cay13122-5 5 mg -

6 - 10 business days*

117.00€
Cay13122-10 10 mg -

6 - 10 business days*

213.00€
Cay13122-25 25 mg -

6 - 10 business days*

477.00€
 
CHIR99021 is an aminopyrimidine derivative that inhibits GSK3alpha and GSK3beta with IC50 values... more
Product information "CHIR99021"
CHIR99021 is an aminopyrimidine derivative that inhibits GSK3alpha and GSK3beta with IC50 values of 10 and 6.7 nM, respectively. When tested against twenty different protein kinases, this inhibitor shows greater than 500-fold selectivity for GSK3. CHIR99021 activates glycogen synthesis in CHO-IR cells (EC50 = 0.763 µM) and in isolated type 1 diabetic rat skeletal muscle. A single oral dose (30 mg/kg) of CHIR99021 enhances in vivo glucose metabolism in a rodent model of type 2 diabetes. CHIR99021 has also been shown to induce the reprogramming of murine and human somatic cells into stem cells.Formal Name: 6-[[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile. CAS Number: 252917-06-9. Synonyms: CT 99021. Molecular Formula: C22H18Cl2N8. Formula Weight: 465.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 2.5 mg/ml. lambdamax: 279 nm. SMILES: N#CC(C=N1)=CC=C1NCCNC2=NC=C(C3=NC(C)=CN3)C(C4=CC=C(Cl)C=C4Cl)=N2. InChi Code: InChI=1S/C22H18Cl2N8/c1-13-10-29-21(31-13)17-12-30-22(32-20(17)16-4-3-15(23)8-18(16)24)27-7-6-26-19-5-2-14(9-25)11-28-19/h2-5,8,10-12H,6-7H2,1H3,(H,26,28)(H,29,31)(H,27,30,32). InChi Key: AQGNHMOJWBZFQQ-UHFFFAOYSA-N.
Keywords: CT 99021, 6-[[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile
Supplier: Cayman Chemical
Supplier-Nr: 13122

Properties

Application: GSK3alpha and GSK3beta inhibitor
MW: 465.3 D
Formula: C22H18Cl2N8
Purity: >95%
Format: Crystalline Solid

Database Information

CAS : 252917-06-9| Matching products
KEGG ID : K03083 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H300, H315, H319, H335
P Phrases: P261, P264, P270, P271, P280, P312, P321, P330, P301+P310, P302+P352, P304+P340, P305+P351+P338, P332+P313, P337+P313, P362+P364, P405, P403+P233, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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