CGK733

Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay16242-5 5 mg -

6 - 10 business days*

77.00€
Cay16242-10 10 mg -

6 - 10 business days*

119.00€
Cay16242-25 25 mg -

6 - 10 business days*

204.00€
Cay16242-50 50 mg -

6 - 10 business days*

295.00€
 
CGK733 is an anticancer compound that was originally identified as an inhibitor of... more
Product information "CGK733"
CGK733 is an anticancer compound that was originally identified as an inhibitor of ataxia-telangiectasia mutated kinase (ATM) and ataxia-telangiectasia and Rad3-related kinase (ATR) in a study that has since been retracted. It inhibits irradiation-induced activation of ATM in a reporter assay using HEK293 cells when used at a concentration of 10 µM but does not inhibit irradiation-induced activation of ATM or checkpoint kinase 2 (Chk2) in H460 human lung cancer cells or UV radiation-induced phosphorylation of Chk1 at serine 317 at the same concentration. It also inhibits ATM activity in a bioluminescence-based reporter D54 glioblastoma mouse xenograft model when administered at a dose of 25 mg/kg. CGK733 reduces tumor growth in a CNE-2 nasopharyngeal carcinoma mouse xenograft model.Formal Name: alpha-phenyl-N-[2,2,2-trichloro-1-[[[(4-fluoro-3-nitrophenyl)amino]thioxomethyl]amino]ethyl]-benzeneacetamide. CAS Number: 905973-89-9. Synonyms: ATM/ATR Kinase Inhibitor. Molecular Formula: C23H18Cl3FN4O3S. Formula Weight: 555.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 50 mg/ml, DMSO: 50 mg/ml, DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml. lambdamax: 240, 275 nm. SMILES: FC1=C([N+]([O-])=O)C=C(NC(NC(C(Cl)(Cl)Cl)NC(C(C2=CC=CC=C2)C3=CC=CC=C3)=O)=S)C=C1. InChi Code: InChI=1S/C23H18Cl3FN4O3S/c24-23(25,26)21(30-22(35)28-16-11-12-17(27)18(13-16)31(33)34)29-20(32)19(14-7-3-1-4-8-14)15-9-5-2-6-10-15/h1-13,19,21H,(H,29,32)(H2,28,30,35). InChi Key: HLCDNLNLQNYZTK-UHFFFAOYSA-N.
Keywords: ATM/ATR Kinase Inhibitor, alpha-phenyl-N-[2,2,2-trichloro-1-[[[(4-fluoro-3-nitrophenyl)amino]thioxomethyl]amino]ethyl]-benzeneacetamide
Supplier: Cayman Chemical
Supplier-Nr: 16242

Properties

Application: ATM inhibitor
MW: 555.8 D
Formula: C23H18Cl3FN4O3S
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 905973-89-9| Matching products
KEGG ID : K04728 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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