CD40L (rat) (multimeric) (rec.)

CD40L (rat) (multimeric) (rec.)
%
Item number Size Datasheet Manual SDS Delivery time Quantity Discount Price
AG-40B-0107-C010 10 µg -

3 - 9 business days*

10 %
352.00€
316.80€
AG-40B-0107-3010 30 µg (3 x 10 µg) -

3 - 9 business days*

10 %
704.00€
633.60€
 
(3 x 10 µg). Rat CD40L (amino acids 115-260) is fused at the N-terminus to mouse ACRP30headless... more
Product information "CD40L (rat) (multimeric) (rec.)"
(3 x 10 µg). Rat CD40L (amino acids 115-260) is fused at the N-terminus to mouse ACRP30headless (amino acids 18-111) and a FLAG(R)-tag. Induces B cells activation (as demonstrated by dose-dependent upregulation of CD86). Lyophilized. Contains PBS. MultimericCD40L is a high activity construct in which two trimeric CD40 ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively simulates the natural membrane-assisted aggregation of CD40L in vivo. It provides a simple and equally potent alternative to CD40L+enhancer combinations. MultimericCD40L has been shown to suppress alum-induced IL-1beta release and caspase-1 activation in a dose-, CD40- and time dependent manner, without affecting BMDM (Bone marrow-derived macrophages) viability. It also effectively suppressed the inflammasome function triggered by NLRP3 activators. The secretion of caspase-1 independent inflammatory mediators has been shown to be unaltered or even enhanced.
Keywords: MegaCD40L(TM), Soluble (rat, rec.), ACRP30headless:CD40L, ACRP30headless:CD154, ACRP30headless:TNFSF5, ADIPOQ-CD40L
Supplier: AdipoGen Life Sciences
Supplier-Nr: AG-40B-0107

Properties

Application: Bioassays
Conjugate: No
Host: Hamster cells
Species reactivity: human, mouse, rat
Format: Lyophilized

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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