CD40L (mouse) (multimeric) (rec.)

CD40L (mouse) (multimeric) (rec.)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
AG-40B-0020-C010 10 µg -

3 - 9 business days*

363.00€
AG-40B-0020-3010 30 µg (3 x 10 µg) -

3 - 9 business days*

726.00€
 
(3 x 10 µg). Mouse CD40L (amino acids 115-260) is fused at the N-terminus to mouse ACRP30headless... more
Product information "CD40L (mouse) (multimeric) (rec.)"
(3 x 10 µg). Mouse CD40L (amino acids 115-260) is fused at the N-terminus to mouse ACRP30headless (amino acids 18-111) and a FLAG(R)-tag. Induces B cells activation (as demonstrated by dose-dependent upregulation of CD86). Lyophilized. Contains PBS. MultimericCD40L is a high activity construct in which two trimeric CD40 ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively simulates the natural membrane-assisted aggregation of CD40L in vivo. It provides a simple and equally potent alternative to CD40L+enhancer combinations. MultimericCD40L has shown to suppress alum-induced IL-1beta release and caspase-1 activation in a dose-, CD40- and time dependent manner, without affecting BMDM (Bone marrow-derived macrophages) viability. It also effectively suppressed the inflammasome function triggered by NLRP3 activators. The secretion of caspase-1 independent inflammatory mediators has been shown to be unaltered or even enhanced.
Keywords: MegaCD40L(TM), Soluble (mouse, rec.), ACRP30headless:CD40L, ACRP30headless:CD154, ACRP30headless:TNFSF5, ADIPOQ-CD40L
Supplier: AdipoGen Life Sciences
Supplier-Nr: AG-40B-0020

Properties

Application: Bioassays
Conjugate: No
Host: Hamster cells
Species reactivity: mouse
Format: Lyophilized

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "CD40L (mouse) (multimeric) (rec.)"
Write a review
or to review a product.
Viewed