CD279 [PD-1] (human):Fc (human) (rec.) (non-lytic)

The extracellular domain of human CD279 [PD-1] (aa 25-167) is fused to the N-terminus of the Fc region of a mutant human IgG1. Lyophilized from 0.2µm-filtered solution in PBS. Shows the biological function of the CD279 moiety and exerts a prolonged circulating half-life caused by the modified Fc domain. Programmed Death-1 (PD-1, CD279) is a type I transmembrane protein belonging to the CD28/CTLA-4 family of immunoreceptors that mediate signals for regulating immune responses. Members of the CD28/CTLA-4 family have been shown to either promote T cell activation (CD28 and ICOS) or downregulate T cell activation (CTLA-4 and PD-1). CD279 is expressed on activated T-cells, B-cells, myeloid cells and on a subset of thymocytes. In vitro, ligation of CD279 inhibits TCR-mediated T-cell proliferation and production of IL-1, IL-4, IL-10 and IFN-gamma. In addition, CD279 ligation also inhibits BCR mediated signaling. CD279 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases.