CD278 [ICOS] (human) -muIg Fusion Protein, R-PE conjugated

A soluble fusion protein consisting of the extracellular (121aa) domain of mature human CD278(ICOS) fused to murine IgG2a Fc (232 aa), with a predicted monomeric molecular weight of 40.4 kd. CD278-muIg binds to recombinant CD275(ICOSL, GL50)-muIg in EIA. The inducible costimulator CD278 (ICOS, T cell activation molecule H4) is similar to human CD28 (24% homology) and plays an analogous role in the T cell activation process. Each secondary signal from CD278 results in a discrete cytokine secretion profile displayed by the activated T cell. Both activation processes are effectively down regulated by CD152 (CTLA-4) engagement.