CD273 [PD-L2] (mouse):Fc (mouse) (rec.)

CD273 [PD-L2] (mouse):Fc (mouse) (rec.)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
CHI-MF-110PDL2-C100 100 µg - -

3 - 9 business days*

429.00€
 
The extracellular domain of mouse CD273 [PD-L2] (aa 20-219) is fused to the N-terminus of the Fc... more
Product information "CD273 [PD-L2] (mouse):Fc (mouse) (rec.)"
The extracellular domain of mouse CD273 [PD-L2] (aa 20-219) is fused to the N-terminus of the Fc region of mouse IgG2a. T cells require a signal induced by the engagement of the T cell receptor and a costimulatory signal(s) through distinct T cell surface molecules for optimal T cell activation and tolerance. CD273 (PD-L2) is one of two ligands for programmed death-1 (PD-1, CD279), a member of the CD28 family of immunoreceptors. The other identified ligand is PD-L1. CD273 is broadly expressed and also up regulated in a variety of tumor cell lines. On previously activated T cells, CD273 interaction with PD-1 inhibits TCR mediated proliferation and cytokine production, suggesting an inhibitory role in regulating immune responses. CD273 has a costimulatory function on resting T cells activated with suboptimal TCR signals.
Keywords: B7dc, PD-L2, CD273, B7-DC, Pdcd1lg2, PD-1 ligand 2, PDCD1 ligand 2, Butyrophilin B7-DC, Programmed death ligand 2, Programmed cell death 1 ligand 2
Supplier: Chimerigen Laboratories
Supplier-Nr: MF-110PDL2

Properties

Application: Bioassays
Conjugate: No
Host: Hamster cells
Species reactivity: mouse
Purity: >98%
Format: Lyophilized

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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