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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
CHI-HF-220CD200-C100 | 100 µg | - | - |
3 - 9 business days* |
512.00€
|
The extracellular domain of human CD200 (aa 31-236) is fused at the C-terminus to the Fc portion... more
Product information "CD200 (human):Fc (human) (rec.) (non-lytic)"
The extracellular domain of human CD200 (aa 31-236) is fused at the C-terminus to the Fc portion of a mutant human IgG1. Lyophilized from 0.2µm-filtered solution in PBS. CD200, also known as OX-2, is a 45 kDa transmembrane immunoregulatory protein that belongs to the immunoglobulin superfamily. CD200 is widely but not ubiquitously expressed. Its receptor (CD200R) is restricted primarily to mast cells, basophils, macrophages, and dendritic cells, which suggests myeloid cell regulation as the major function of CD200. CD200 knockout mice are characterized by increased macrophage number and activation and are predisposed to autoimmune disorders. In T cells, CD200 functions as a costimulatory molecule independent of the CD28 pathway. Several viruses encode CD200 homologs which are expressed on infected cells during the lytic phase. Like CD200 itself, viral CD200 homologs also suppress myeloid cell activity, enabling increased viral propagation.
Keywords: | MOX1, CD200, My033, OX-2 membrane glycoprotein |
Supplier: | Chimerigen Laboratories |
Supplier-Nr: | HF-220CD200 |
Properties
Application: | Bioassays |
Conjugate: | No |
Host: | Hamster cells |
Species reactivity: | human |
Purity: | >98% |
Format: | Lyophilized |
Database Information
KEGG ID : | K06556 | Matching products |
UniProt ID : | P41217 | Matching products |
Gene ID | GeneID 4345 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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