CD152 [CTLA-4] (human):Fc (human) (rec.)

CD152 [CTLA-4] (human):Fc (human) (rec.)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
CHI-HF-210A4-C100 100 µg - -

3 - 9 business days*

121.00€
CHI-HF-210A4-C500 500 µg - -

3 - 9 business days*

325.00€
 
The extracellular domain of human CD152 [CTLA-4] is fused at the C-terminus to the Fc portion of... more
Product information "CD152 [CTLA-4] (human):Fc (human) (rec.)"
The extracellular domain of human CD152 [CTLA-4] is fused at the C-terminus to the Fc portion of human IgG1. Lyophilized from 0.2µm-filtered solution in PBS. Binds both CD80 (B7-1) and CD86 (B7-2) with high affinity and inhibits CD28 signaling competitively. Kills the target cell completely. CD152 [CTLA-4] and CD28, together with their ligands B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD152 and CD28 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. Both CD152 and CD28 are composed of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain. CD152 and CD28 are both expressed on the cell surface as disulfide-linked homodimers or as monomers. CD152 was originally identified as a gene that was specifically expressed by cytotoxic T lymphocytes. However, CD152 transcripts have since been found in both Th1 and Th2, and CD4 and CD8 T cell clones. Whereas, CD28 expression is constitutive on the surfaces of 95% of CD4 T cells and 50% of CD8 T cells and is down regulated upon T cell activation, CD152 expression is upregulated rapidly following T cell activation and peaks approximately 24 hours following activation. Although both CD152 and CD28 can bind to the same ligands, CD152 binds to B71 and B72 with 20-100-fold higher affinity than CD28.
Keywords: CTLA4, CD152, CTLA-4, Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4
Supplier: Chimerigen Laboratories
Supplier-Nr: HF-210A4

Properties

Application: Bioassays
Conjugate: No
Host: Mouse cells
Species reactivity: human
Purity: >98%
Format: Lyophilized

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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