CAY10638

Prostaglandins have a short life in vivo because NAD+-dependent 15-hydroxy prostaglandin dehydrogenase (15-PGDH) catalyzes their oxidation to 15-keto metabolites with greatly reduced biological activity. Thiazolidinediones (TZDs) are a class of PPARgamma agonists that have potent 15-PGDH inhibitory activity. CAY10638 is a TZD derivative that inhibits 15-PGDH activity with an IC50 value of 31 nM.Formal Name: 5-[[4-[2-(2-thienyl)ethoxy]phenyl]methylene]-2,4-thiazolidinedione. CAS Number: 1221413-57-5. Synonyms: Thiazolidinedione derivative. Molecular Formula: C16H13NO3S2. Formula Weight: 331.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml, DMSO: 25 mg/ml. lambdamax: 234, 343 nm. SMILES: O=C(/C(S1)=C/C(C=C2)=CC=C2OCCC3=CC=CS3)NC1=O. InChi Code: InChI=1S/C16H13NO3S2/c18-15-14(22-16(19)17-15)10-11-3-5-12(6-4-11)20-8-7-13-2-1-9-21-13/h1-6,9-10H,7-8H2,(H,17,18,19)/b14-10-. InChi Key: NTKWOUHXDKSPIX-UVTDQMKNSA-N.