Benzisoxazole Hsp90 Inhibitor

Benzisoxazole Hsp90 inhibitor is an inhibitor of heat shock protein 90 (Hsp90, IC50 = 30 nM in a fluorescence polarization assay). It is selective for Hsp90 over a panel of kinases (IC50s = >20 µM). Benzisoxazole Hsp90 inhibitor inhibits the proliferation of HCT116, SK-BR-3, LNCaP, DU145, and H157 cancer cells (IC50s = 0.28, 0.37, 0.17, 0.29, and 0.23 µM, respectively). It also induces degradation of the Hsp90 targets HER2 and the androgen receptor in SK-BR-3 and LNCaP cells, respectively, with an IC50 value of 0.33 µM for both.Formal Name: 4-chloro-6-[5-[[2-(4-morpholinyl)ethyl]amino]-1,2-benzisoxazol-3-yl]-1,3-benzenediol. CAS Number: 1012788-65-6. Synonyms: BHI. Molecular Formula: C19H20ClN3O4. Formula Weight: 389.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 25 mg/ml, Ethanol:PBS (pH 7.2) (1:10): 0.1 mg/ml. lambdamax: 230, 316, 359 nm. SMILES: Oc1cc(O)c(cc1Cl)c1noc2ccc(NCCN3CCOCC3)cc12. InChi Code: InChI=1S/C19H20ClN3O4/c20-15-10-13(16(24)11-17(15)25)19-14-9-12(1-2-18(14)27-22-19)21-3-4-23-5-7-26-8-6-23/h1-2,9-11,21,24-25H,3-8H2. InChi Key: JLIRVZVVCCIAKG-UHFFFAOYSA-N.