CAY10597

CAY10597
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10012539-1 1 mg -

6 - 10 business days*

96.00€
Cay10012539-5 5 mg -

6 - 10 business days*

419.00€
Cay10012539-10 10 mg -

6 - 10 business days*

742.00€
 
The biological effects of prostaglandin D2 (PGD2) are transduced by at least two 7-transmembrane... more
Product information "CAY10597"
The biological effects of prostaglandin D2 (PGD2) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP1 and CRTH2/DP2. In humans, CRTH2/DP2 is expressed on Th2 cells, eosinophils, and basophils where it mediates the chemotactic activity of PGD2. CAY10597, as a racemic mixture, is a potent CRTH2/DP2 receptor antagonist that binds to the human receptor with a Ki value of 37 nM. The R enantiomer is slightly more potent exhibiting Ki values of 23 and 22 nM at the human and murine CRTH2/DP2 receptor, respectively. The R enantiomer of CAY10597 inhibits eosinophil chemotaxis induced by 13,14-dihydro-15-keto-prostaglandin D2 with an IC50 value of 40 nM.Formal Name: 5-chloro-1'-[(2-fluorophenyl)methyl]-2,2',5'-trioxo-spiro[3H-indole-3,3'-pyrrolidine-1(2H)-acetic acid. CAS Number: 916046-55-4. Molecular Formula: C20H14ClFN2O5. Formula Weight: 416.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 20 mg/ml, PBS (pH 7.2): 0.30 mg/ml. lambdamax: 208, 259 nm. SMILES: OC(=O)CN1c2ccc(Cl)cc2C2(CC(=O)N(Cc3ccccc3F)C2=O)C1=O. InChi Code: InChI=1S/C20H14ClFN2O5/c21-12-5-6-15-13(7-12)20(18(28)23(15)10-17(26)27)8-16(25)24(19(20)29)9-11-3-1-2-4-14(11)22/h1-7H,8-10H2,(H,26,27). InChi Key: SKLDVYDFQCXARY-UHFFFAOYSA-N.
Keywords: 5-chloro-1'-[(2-fluorophenyl)methyl]-2,2',5'-trioxo-spiro[3H-indole-3,3'-pyrrolidine-1(2H)-acetic acid
Supplier: Cayman Chemical
Supplier-Nr: 10012539

Properties

Application: CRTH2receptor antagonist, DP2 receptor antagonist
MW: 416.8 D
Formula: C20H14ClFN2O5
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 916046-55-4| Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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