CAY10416

CAY10416
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay70635-1 1 mg -

6 - 10 business days*

77.00€
Cay70635-5 5 mg -

6 - 10 business days*

333.00€
Cay70635-10 10 mg -

6 - 10 business days*

586.00€
 
Dual cyclooxygenase-2 (COX-2)/5-lipoxygenase (5-LO) inhibitors are potential therapeutic agents... more
Product information "CAY10416"
Dual cyclooxygenase-2 (COX-2)/5-lipoxygenase (5-LO) inhibitors are potential therapeutic agents for inflammatory diseases and for prostate cancer. CAY10416 is a dual COX-2/5-LO inhibitor with IC50 values of 50 and 3 nM, respectively. The selectivity of CAY10416 for COX is greater than 200-fold for COX-2 versus COX-1. COX-2/5-LO inhibitors such as CAY10416 are also apoptosis-inducing agents and are potentially useful in prostate cancer chemotherapy. In the PC3 human carcinoma cell line, CAY10416 exhibits a 45% inhibition of proliferation at 100 µM. In the LNCaP human carcinoma cell line, CAY10416 inhibits growth with an IC50 value of 83 µM.Formal Name: 3-[[3-fluoro-5-(tetrahydro-4-methoxy-2H-pyran-4-yl)phenoxy]methyl]-1-[4-(methylsulfonyl)phenyl]-5-phenyl-1H-pyrazole. CAS Number: 443919-96-8. Molecular Formula: C29H29FN2O5S. Formula Weight: 536.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 5 mg/ml. lambdamax: 204, 269 nm. SMILES: COC1(CCOCC1)c1cc(OCc2cc(c3ccccc3)n(n2)c2ccc(cc2)S(=O)(=O)C)cc(F)c1. InChi Code: InChI=1S/C29H29FN2O5S/c1-35-29(12-14-36-15-13-29)22-16-23(30)18-26(17-22)37-20-24-19-28(21-6-4-3-5-7-21)32(31-24)25-8-10-27(11-9-25)38(2,33)34/h3-11,16-19H,12-15,20H2,1-2H3. InChi Key: WSCRVCJAJAXULJ-UHFFFAOYSA-N.
Keywords: 3-[[3-fluoro-5-(tetrahydro-4-methoxy-2H-pyran-4-yl)phenoxy]methyl]-1-[4-(methylsulfonyl)phenyl]-5-phenyl-1H-pyrazole
Supplier: Cayman Chemical
Supplier-Nr: 70635

Properties

Application: COX-2 inhibitor, 5-LO inhibitor
MW: 536.6 D
Formula: C29H29FN2O5S
Purity: >95%
Format: Crystalline Solid

Database Information

CAS : 443919-96-8| Matching products
KEGG ID : K11987 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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