- Search results for Cay70210
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15 products were found matching "Cay70210"!
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Item number: Cay70210-1
CAY10404 is an inhibitor of COX-2 (IC50 = 50 = >500 µM). CAY10404 inhibits the proliferation of SH-EP and SH-SY5Y neuroblastoma cells (IC50s = ~60 µM for both), and induces apoptosis and cell cycle arrest at the G2/M phase in the same cells. It inhibits carrageenan-induced paw edema in rats when administered at a...
Keywords: | 3-[4-(methylsulfonyl)phenyl]-4-phenyl-5-(trifluoromethyl)-isoxazole |
Application: | COX-2 inhibitor |
CAS | 340267-36-9 |
MW: | 367.4 D |
From 31.00€
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Item number: Cay700210-96
DPP (IV) inhibitors have emerged as a new class of oral antidiabetic agents. These inhibitors promote glucose homeostasis by inhibiting degradation of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) by DPP (IV). GLP-1 extends the action of insulin while suppressing the release...
Keywords: | Dipeptidyl peptidase IV |
Application: | DPP (IV) inhibitor screening |
Species reactivity: | human |
467.00€
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Item number: Cay702210-1
Cayman's GGT Activity Assay Kit provides a convenient method of detecting GGT activity in plasma, serum, and tissue lysates. In this assay, GGT catalyzes the transfer of the gamma-glutamyl group from L-gamma-glutamyl-p-nitroaniline (gammaGpNA) to glycylglycine resulting in the liberation of the colored product...
Keywords: | GGT |
661.00€
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Item number: Cay702160-384
Cayman's TXAS Inhibitor Screening Assay Kit provides a robust and easy-to-use platform for identifying novel inhibitors of human TXAS. The assay uses a TAMRA-conjugated TXAS-specific probe suitable for fluorescence polarization (FP)-based screening of TXAS inhibitors. Inhibitors of TXAS displace the fluorescent...
Keywords: | CYP5A1, Cytochrome P450 5A1, TBXAS1, TXA Synthase, TXAS, TXS, CYP5, Thromboxane-A synthase, Hydroperoxy icosatetraenoate... |
Application: | Human TXAS inhibitor screening, fluorescence polarization |
669.00€
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Item number: Cay70265-10
5-Aminosalicylic acid (5-ASA) is a non-steroidal anti-inflammatory drug (NSAID) and an active metabolite of sulfasalazine (Cay-15025), balsalazide (Cay-18680), and olsalazine (Cay-23661). It is formed from these prodrugs by bacterial azoreductases in the intestinal lumen. 5-ASA selectively inhibits COX-2 over COX-1...
Keywords: | 5-ASA, Mesalamine, Mesalazine, 5-amino-2-hydroxy-benzoic acid |
Application: | COX inhibitor |
CAS | 89-57-6 |
MW: | 153.1 D |
From 22.00€
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Item number: Cay70230-10
LY83583 is an inhibitor of soluble guanylate cyclase and of cGMP production. It inhibits soluble guanylate cyclase in human platelets with an IC50 value of 2 µM. LY83583 also inhibits leukotriene synthesis in guinea pig lung and rat peritoneal cells with an IC50 value of 1.8 µM and is a noncompetitive inhibitor of...
Keywords: | 6-(phenylamino)-5,8-quinolinedione |
Application: | Guanylate cyclase inhibitor |
CAS | 91300-60-6 |
MW: | 250.3 D |
From 24.00€
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Item number: Cay70275-10
IMMA is a cannabinoid (CB) receptor 2 inverse agonist (Ki = 435 nM for recombinant human CB2). It is selective for CB2 over CB1 receptors (Ki = >20 µM). IMMA (0.001-1 µM) reduces basal production of inositol phosphate and increases forskolin-induced accumulation of cAMP in HEK293 cells expressing human CB2...
Keywords: | BML-190, Indomethacin Morpholinylamide, LM-4131,... |
Application: | CB2 receptor agonist |
CAS | 2854-32-2 |
MW: | 426.9 D |
From 35.00€
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Item number: Cay70271-10
Indomethacin is a potent but non-selective inhibitor of both COX-1 and COX-2 in sheep and humans. Structurally, indomethacin is a substituted indole acetic acid, wherein the carboxylate can be derivatized as an ester or amide. These derivatives show enhanced selectivity for the COX-2 isoform. For example, the IC50...
Keywords: | 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid, 1-heptyl ester |
Application: | COX-2 inhibitor |
CAS | 282728-47-6 |
MW: | 456 D |
From 34.00€
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Item number: Cay70273-10
Indomethacin is a potent but non-selective inhibitor of both COX-1 and COX-2 in sheep and humans. Structurally, indomethacin is a substituted indole acetic acid, wherein the carboxylate can be derivitized as an ester or amide. These derivatives show enhanced selectivity for the COX-2 isoform. For example, the IC50...
Keywords: | N-octyl-1-(4-chlorobenzoyl)-5-methoxy-1H-indole-3-acetamide |
Application: | COX-2 inhibitor |
CAS | 282728-65-8 |
MW: | 469 D |
From 34.00€
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Item number: Cay70263-10
O-Acetyl Salicylhydroxamic Acid (O-ASHA) is an irreversible, non-selective inhibitor of COX-1 and COX-2. Aspirin is the best-studied example of an irreversible COX inhibitor, acting via the acetylation of the active site serine residue 529 in human COX-1. O-ASHA inhibits ovine COX-1 in a time-dependent, irreversible...
Keywords: | AcSHA, O-ASHA, N-(acetyloxy)-2-hydroxy benzamide |
Application: | COX inhibitor |
CAS | 199854-00-7 |
MW: | 195.2 D |
From 26.00€
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Item number: Cay70272-10
N-(2-phenylethyl)-indomethacin amide (N-2PIA) is one of several aromatic amides of indomethacin reported to be potent and selective reversible inhibitors of COX-2. N-2PIA inhibits human recombinant and ovine COX-2 with IC50 values of 0.06 and 0.125 µM, respectively. It is over 400 times less potent as an inhibitor...
Keywords: | N-2PIA, N-(2-phenylethyl)-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetamide |
Application: | COX-2 inhibitor |
CAS | 261766-32-9 |
MW: | 461 D |
From 24.00€
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Item number: Cay70274-10
N-(3-pyridyl)-indomethacin amide (N-3PyIA) is one of several aromatic amides of indomethacin reported to be potent and selective reversible inhibitors of COX-2. N-3PyIA selectively inhibits human recombinant COX-2 with an IC50 of 0.052 µM. It is about 1,300 times less potent as an inhibitor of ovine recombinant...
Keywords: | N-3PyIA, N-(3-pyridyl)-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetamide |
Application: | COX-2 inhibitor |
CAS | 261766-29-4 |
MW: | 433.9 D |
From 24.00€
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