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Butein is a plant polyphenol that is classified as a chalcone, due to the propenone linkage between the phenol groups. Like other polyphenols, butein is a potent antioxidant and affects the numerous pathways modulated by oxidant tone, including inflammation, cancer, and immune response. It inhibits 5-lipoxygenase, the enoyl-acyl-carrier protein reductase of P. falciparum, angiotensin-converting enzyme, and Src kinase (IC50 or Ki values of 0.01, 2.97, 0.73, and 65 µM, respectively). Butein is also a sirtuin activator, increasing trichostatin A (Cay-89730)-insensitive deacetylase activity.Formal Name: (2E)-1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-2-propen-1-one. CAS Number: 487-52-5. Synonyms: 2',3,4,4'-tetrahydroxy Chalcone. Molecular Formula: C15H12O5. Formula Weight: 272.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 20 mg/ml, Ethanol: 20 mg/ml. lambdamax: 262, 348, 382 nm. SMILES: OC1=C(O)C=CC(/C=C/C(C2=C(O)C=C(O)C=C2)=O)=C1. InChi Code: InChI=1S/C15H12O5/c16-10-3-4-11(14(19)8-10)12(17)5-1-9-2-6-13(18)15(20)7-9/h1-8,16,18-20H/b5-1+. InChi Key: AYMYWHCQALZEGT-ORCRQEGFSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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