- Search results for SYN-1021-M100
Cookie preferences
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Track device being used
16 products were found matching "SYN-1021-M100"!
Close filters
Filter by:
No results were found for the filter!
Item number: SYN-1012-M100
Soluble in DMSO or ethanol. AV-412 is a potent dual inhibitor of EGFR and ErbB2 tyrosine kinases, including the mutant EGFR(L858R,T790M), which is clinically resistant to the EGFR-specific kinase inhibitors erlotinib and gefitinib. In enzyme assays assay the compound inhibited the EGFR variants and ErbB2 in the...
Keywords: | MP-412, AV412 |
Application: | EGFR / ErbB2 inhibitor |
CAS | 451492-95-8 |
MW: | 507 D |
Please request pricing for this article.
Item number: SYN-1201-M100
Soluble in DMSO or ethanol. GSK2606414 is an orally available, potent, and selective PERK inhibitor with IC(50) of 0.4nM, displaying at least 100-fold selectivity over the other EIF2AKs assayed Target: PERK , Kinase Group: Other , Substrate: Serine-Threonine
Keywords: | GSK-2606414 |
Application: | EIF2AK3 / PERK inhibitor |
CAS | 1337531-36-8 |
MW: | 451,4 D |
Please request pricing for this article.
Item number: SYN-1121-M001
Soluble in DMSO or ethanol. R406 is a strong Syk inhibitor with an IC(50) of 41nM. It inhibits Syk but not Lyn. It shows 5-fold less potency to Flt3. Target: Syk , Kinase Group: PTK , Substrate: Tyrosine
Keywords: | R-406 |
Application: | Syk inhibitor |
CAS | 841290-80-0 |
MW: | 470,5 D |
From 132.00€
*
Item number: SYN-1027-M100
Soluble in DMSO or ethanol. BX912 is a PDK1 (3-Phosphoinositide-dependent Kinase-1) inhibitor, with an IC(50) of 26nM. Target: PDK1 , Kinase Group: AGC , Substrate: Serine-Threonine
Keywords: | BX912 |
Application: | PDPK1 inhibitor |
CAS | 702674-56-4 |
MW: | 471,4 D |
Please request pricing for this article.
Item number: SYN-1024-M100
Soluble in DMSO. Kinases, such as LIM kinase 1 (LIMK1) and LIM kinase 2 (LIMK2), have been identified as participating in signal pathways affecting actin dynamics by deactivating cofilin. Over expression of LMK1 has been found in invasive breast and prostate cancer cell lines and suppression of LIMK 2 expression has...
Keywords: | BMS5 |
Application: | LIMK1 / LIMK2 inhibitor |
CAS | 1338247-35-0 |
MW: | 431,3 D |
Please request pricing for this article.
Item number: SYN-1028-M100
Soluble in DMSO. CC-401 is a competitive inhibitor of the ATP binding site in the active, phosphorylated, form of JNK. This prevents JNK from phosphorylating its various target molecules, including the amino terminus of c-Jun. It is a potent inhibitor of all three forms of JNK (Ki of 25-50 nM), and has at least...
Keywords: | CC401 |
Application: | JNK inhibitor |
CAS | 1438391-30-0 |
MW: | 424,9 D |
Please request pricing for this article.
Item number: SYN-1041-M100
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. GDC-0941 is a potent class I PI3 kinase (PI3K) inhibitor. It selectively binds to PI3K isoforms in an ATP-competitive manner. It has an IC(50) of 3nM, and shows slight selectivity toward p110beta (11-fold) and p110gamma (25-fold). Target: PI3K , Kinase Group:...
Keywords: | GDC0941 |
Application: | PI3K inhibitor |
CAS | 957054-30-7 |
MW: | 513,6 D |
Please request pricing for this article.
Item number: SYN-1081-M100
Soluble in DMSO or ethanol. Aurora kinases constitute a family of serine-threonine kinases that are strongly associated with cancer. Aurora A and B are essential in mitosis. Perturbation of their activity leads to multiple defects in mitosis including aberrant centrosome duplication, misalignment of chromosomes,...
Keywords: | SNS314 |
Application: | Aurora inhibitor |
CAS | 1057249-41-8 |
MW: | 430,9 D |
Please request pricing for this article.
Item number: SYN-1001-M100
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. ABT-737 is a small-molecule inhibitor of the anti-apoptotic proteins Bcl-2, Bcl-X(L) and Bcl-w, with an affinity two to three orders of magnitude more potent than previously reported compounds. Mechanistic studies reveal that ABT-737 does not directly initiate...
Keywords: | ABT737 |
Application: | Bcl-2 / Bcl-X(L) / Bcl-w inhibitor |
CAS | 852808-04-9 |
MW: | 813,4 D |
Please request pricing for this article.
Item number: SYN-1011-M100
Soluble in DMSO or ethanol. Aurora kinases play a key role in the regulation of mitosis and in recent years have become attractive targets for the treatment of cancer. AT9283 is a powerful inhibitor of Aurora A and B kinases as well as several other important kinases including JAK2 and Abl (T315I). AT9283 has also...
Keywords: | AT-9283 |
Application: | Aurora inhibitor |
CAS | 896466-04-9 |
MW: | 381,4 D |
Please request pricing for this article.
Item number: SYN-1061-M100
PD173955 is an ATP-competitive, dual Src/Abl kinase inhibitor. It is a potent inhibitor of Bcr-Abl with an IC(50) of 1-2nM in kinase inhibition assays. In cellular growth assays it inhibits Bcr-Abl-dependent substrate tyrosine phosphorylation. PD173955 also inhibits Src kinase activity in vitro with an IC(50) of...
Keywords: | PD173955, PD-173,955 |
Application: | BCR-Abl inhibitor |
CAS | 260415-63-2 |
MW: | 443,4 D |
Please request pricing for this article.
Item number: SYN-1020-M100
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. BI-D1870 is a small molecule, specific inhibitor of p90 RSK (ribosomal S6 kinase) isoforms RSK1, RSK2, RSK3 and RSK4, both in vitro and in vivo, with IC(50)s are 31nM, 24nM, 18nM, 15nM, respectively. It shows a 10- to 100-fold selectivity for RSK over MST2,...
Keywords: | BID1870 |
Application: | RPS6KA inhibitor |
CAS | 501437-28-1 |
MW: | 391,4 D |
Please request pricing for this article.