Bisindolylmaleimide II

Bisindolylmaleimide II
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay11020-1 1 mg -

6 - 10 business days*

77.00€
Cay11020-5 5 mg -

6 - 10 business days*

230.00€
 
Bisindolylmaleimide II (BIM II) is a general inhibitor of all protein kinase C (PKC) subtypes... more
Product information "Bisindolylmaleimide II"
Bisindolylmaleimide II (BIM II) is a general inhibitor of all protein kinase C (PKC) subtypes with structural similarity to the nonspecific PKC inhibitor staurosporine. At 10 µM, BIM II inhibits 98% of PKCalpha kinase activity. Additionally, it inhibits PDK1 (IC50 = 14 µM), an important kinase in the insulin signaling pathway, and PKA (IC50 = 2.94 µM). Studies of structure-activity relationships of BIM II in complex with PDK1 and PKA kinase binding domains has led to useful insights into kinase/ligand binding for the rational design of inhibitors as potential therapeutic agents.Formal Name: 3-(1H-indol-3-yl)-4-[1-[2-(1-methyl-2-pyrrolidinyl)ethyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione. CAS Number: 137592-45-1. Synonyms: BIM II. Molecular Formula: C27H26N4O2. Formula Weight: 438.5. Purity: >97% (isomer mixture). Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble, Ethanol: soluble. SMILES: CN1CCCC1CCN2C3=CC=CC=C3C(C4=C(C5=CNC6=C5C=CC=C6)C(NC4=O)=O)=C2. InChi Code: InChI=1S/C27H26N4O2/c1-30-13-6-7-17(30)12-14-31-16-21(19-9-3-5-11-23(19)31)25-24(26(32)29-27(25)33)20-15-28-22-10-4-2-8-18(20)22/h2-5,8-11,15-17,28H,6-7,12-14H2,1H3,(H,29,32,33). InChi Key: LBFDERUQORUFIN-UHFFFAOYSA-N.
Keywords: BIM II, 3-(1H-indol-3-yl)-4-[1-[2-(1-methyl-2-pyrrolidinyl)ethyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione
Supplier: Cayman Chemical
Supplier-Nr: 11020

Properties

Application: PKC inhibitor
MW: 438.5 D
Formula: C27H26N4O2
Purity: >97% (isomer mixture)
Format: Crystalline Solid

Database Information

CAS : 137592-45-1| Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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