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Benztropine is an antagonist of M1 muscarinic acetylcholine receptors (Ki = 0.59 nM in rat brain membranes). It is selective for M1 receptors over the serotonin transporter (Ki = 5,150 nM), however, it also binds to the dopamine transporter and inhibits dopamine reuptake (Kis = 237 and 130 nM, respectively). Benztropine also inhibits acid sphingomyelinase by 87% when used at a concentration of 10 mM. Formulations containing benztropine have been used in the management of Parkinson's disease symptoms such as involuntary tremor and dystonia.Formal Name: (3-endo)-3-(diphenylmethoxy)-8-methyl-8-azabicyclo[3.2.1]octane, monomethanesulfonate. CAS Number: 132-17-2. Synonyms: NSC 169913. Molecular Formula: C21H25NO . CH3SO3H. Formula Weight: 403.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: CN1[C@@H]2C[C@@H](OC(C3=CC=CC=C3)C4=CC=CC=C4)C[C@H]1CC2.OS(C)(=O)=O. InChi Code: InChI=1S/C21H25NO.CH4O3S/c1-22-18-12-13-19(22)15-20(14-18)23-21(16-8-4-2-5-9-16)17-10-6-3-7-11-17,1-5(2,3)4/h2-11,18-21H,12-15H2,1H3,1H3,(H,2,3,4)/t18-,19+,20+,. InChi Key: CPFJLLXFNPCTDW-BWSPSPBFSA-N.
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