- Search results for Cay10532-1
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5 products were found matching "Cay10532-1"!
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Item number: Cay10531-1
ER-819762 is an antagonist of the prostaglandin E2 (PGE2, Cay-14010) receptor subtype EP4 (IC50 = 70 nM). It is selective for EP4 over EP1, EP2, and EP3 in a cAMP reporter assay at 10 µM. ER-819762 reduces differentiation of mouse helper T cells when used at concentrations ranging from 0.1 to 10 nM and decreases...
Keywords: | (10S)-1'-[(3,5-dimethylphenyl)methyl]-2-ethyl-5,10-dihydro-7,9-dimethoxy-10-methyl-spiro[1H-imidazo[1,5-b][2]benzazepine-1... |
Application: | EP4 antagonist |
CAS | 1155773-15-1 |
MW: | 489.7 D |
From 104.00€
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Item number: Cay15321-10
Kanamycin A is a broad spectrum antibiotic isolated from a soil streptomyces (S. kanamyceticus). This aminoglycoside alters translation by prokaryotic ribosomes, resulting in bacterial cell death. In molecular biology, kanamycin A is used as a selective agent to isolate transformants that are expressing a kanamycin...
Keywords: | Ophtalmokalixan,... |
Application: | Antibiotic |
CAS | 25389-94-0 |
MW: | 582.6 D |
From 77.00€
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Item number: Cay10012539-1
The biological effects of prostaglandin D2 (PGD2) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP1 and CRTH2/DP2. In humans, CRTH2/DP2 is expressed on Th2 cells, eosinophils, and basophils where it mediates the chemotactic activity of PGD2. CAY10597, as a racemic mixture, is...
Keywords: | 5-chloro-1'-[(2-fluorophenyl)methyl]-2,2',5'-trioxo-spiro[3H-indole-3,3'-pyrrolidine-1(2H)-acetic acid |
Application: | CRTH2receptor antagonist, DP2 receptor antagonist |
CAS | 916046-55-4 |
MW: | 416.8 D |
From 96.00€
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Item number: Cay10012536-1
Peroxisome proliferator-activated receptors (PPARs) alpha, delta, gamma are ligand-activated nuclear transcription factors involved in the regulation of energy homeostasis as well as insulin sensitivity and glucose metabolism. Pharmacologies of PPARdelta receptor agonists, though relatively obscure, have recently...
Keywords: | 2-[4-[[3,3-bis(4-bromophenyl)-2-propen-1-yl]thio]-2-chlorophenoxy]-acetic acid |
Application: | PPARdelta agonist |
CAS | 685139-10-0 |
MW: | 568.7 D |
From 48.00€
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Item number: Cay10523-5
Sirtinol is a cell-permeable inhibitor of sirtuin NAD+-dependent deacetylases, inhibiting the yeast sirtuin Sir2p with an IC50 value of 68 µM and the human sirtuins SIRT1 and SIRT2 with IC50 values of 131 and 38 µM, respectively. It does not alter HDAC1 activity. Sirtinol inhibits the growth of cancer cells and...
Keywords: | Sir Two Inhibitor Naphthol, 2-[[(2-hydroxy-1-naphthalenyl)methylene]amino]-N-(1-phenylethyl)-benzamide |
Application: | Sirtuin inhibitor |
CAS | 410536-97-9 |
MW: | 394.5 D |
From 92.00€
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