13 products were found matching "Cay11284-50"!

Chk2 inhibitor is an inhibitor of checkpoint kinase 2 (Chk2, IC50 = 13.5 nM). It is selective for Chk2 over Chk1 (IC50 = 220.4 nM). It inhibits Chk2 autophosphorylation at the serine in position 516 in non-cancerous 184B5 cells that contain wild-type p53 and in MDA-MB-231 cells that contain mutated p53 when used at...

4-deoxy Nivalenol is a trichothecene mycotoxin that has been found in Fusarium. It binds to eukaryotic ribosomes and inhibits protein synthesis in mice when administered at doses ranging from 5 to 25 mg/kg. 4-deoxy Nivalenol (0.1 and 0.2 mg/kg) induces emesis in pigs and decreases feed consumption in pigs when...

Pogostemon (patchouli) leaves and their extracted oils are used in perfumes and in traditional medicine to relieve sunstroke, stop vomiting, and increase appetite. Patchouli alcohol is a sesquiterpene alcohol found in patchouli oil. It has antibacterial, antifungal, and antiviral actions. Patchouli alcohol also...

Goat anti-GST (Glutathione-S-Transferase) IgG conjugated to DyLight(R) 550 Antibody: Goat polyclonal anti-GST IgG Dye: DyLight(R) 550 Excitation max. lambda: 562 nm Emission max. lambda: 576 nm Uses: Fluorescence-activated cell sorting, flow cytometry, and protein microarraysEmission: 576 nm. Excitation: 562 nm....

Rabbit Anti-HA (Hemagglutinin) IgG conjugated to DyLight(R) 488 Antibody:Rabbit polyclonal Anti-HA (YPYDVPDYA) IgG Dye: DyLight(R) 488 Excitation max. lambda: 493 nm Emission max. lambda: 518 nm Isotype: IgG Uses: Fluorescence-activated cell sorting, flow cytometry, and protein microarraysEmission: 518 nm....

TLR agonist 2 is a toll-like receptor 7 (TLR7) agonist with a lowest effective concentration (LEC) value of 0.4 µM in a cell-based reporter assay. It is selective for TLR7 over TLR8 (LEC = >100 µM). TLR7 agonist 2 (0.3-10 mg/kg) increases IFN-alpha levels and the IFN-stimulated gene (ISG) response, increasing the...

Gabapentin-d4 is intended for use as an internal standard for the quantification of gabapentin (Cay-10008346) by GC- or LC-MS. Gabapentin is a gamma-aminobutyric acid (GABA) analogue that acts as an anticonvulsant. It does not bind to GABA receptors, does not influence neural uptake of GABA, and does not inhibit the...

Fludarabine is an intermediate active metabolite of the prodrug fludarabine phosphate (Cay-14251). It is produced by the dephosphorylation of fludarabine phosphate in vivo and re-phosphorylation intracellularly to 2-fluoro-ara-ATP, another active metabolite. Fludarabine inhibits the proliferation of RPMI-8226,...

Bacoside A3 is a triterpenoid saponin first isolated from B. monniera. Bacoside A3 inhibits the ATP-binding cassette transporter P-glycoprotein (P-gp), decreasing efflux 4-fold compared with control in vitro. An extract containing bacoside A3 and bacopaside II (4 and 1.3 µg/mg extract, respectively) administered for...

10-Gingerol is a phenol that has been found in Z. officinale and has diverse biological activities. It scavenges DPPH (Cay-14805), superoxide, and hydroxyl radicals in cell-free assays (IC50s = 10.47, 1.68, and 1.35 µM, respectively) and inhibits oxidative burst induced by N-formyl-Met-Leu-Phe (fMLP, Cay-21495) in...

VX-661 is an investigational compound that promotes the maturation of delta F508 mutants of the cystic fibrosis transmembrane conductance regulator (CFTR). Delta F508 CFTR represents a class of CFTR mutation that is characterized by impaired processing of misfolded CFTR proteins and reduced accumulation of the...

Withanone is a phytochemical that has been found in W. somnifera and has diverse biological activities. It inhibits the protein-protein interaction between human angiotensin-converting enzyme 2 (ACE2) and the SARS-CoV-2 spike protein receptor-binding domain (IC50 = 0.33 ng/ml). Withanone (10 µg/ml) protects against...